{"id":"epoetin-alfa-biomanguinhos","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Hypertension"},{"rate":"10-20","effect":"Headache"},{"rate":"5-10","effect":"Thrombotic events (DVT, PE, stroke)"},{"rate":"5-15","effect":"Injection site reactions"},{"rate":"5-10","effect":"Fever"},{"rate":"5-10","effect":"Arthralgias"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Epoetin alfa is a recombinant human erythropoietin that mimics the natural hormone responsible for regulating red blood cell production. It binds to erythropoietin receptors on erythroid progenitor cells in the bone marrow, triggering proliferation and differentiation into mature red blood cells. This mechanism is used to treat anemia by increasing hemoglobin and hematocrit levels.","oneSentence":"Epoetin alfa stimulates erythropoiesis by binding to erythropoietin receptors on bone marrow progenitor cells, promoting red blood cell production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:15.096Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anemia associated with chronic kidney disease"},{"name":"Anemia in patients with cancer receiving chemotherapy"},{"name":"Anemia in patients undergoing major surgery"}]},"trialDetails":[{"nctId":"NCT01184495","phase":"PHASE3","title":"Efficacy Study of Two Formulations of Erythropoietin","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2008-04","conditions":"Comparison of the Efficacy of Two Formulations of Epoetin in Patients Undergoing Hemodialysis","enrollment":74}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Epoetin Alfa-BioManguinhos","genericName":"Epoetin Alfa-BioManguinhos","companyName":"Hospital de Clinicas de Porto Alegre","companyId":"hospital-de-clinicas-de-porto-alegre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epoetin alfa stimulates erythropoiesis by binding to erythropoietin receptors on bone marrow progenitor cells, promoting red blood cell production. Used for Anemia associated with chronic kidney disease, Anemia in patients with cancer receiving chemotherapy, Anemia in patients undergoing major surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}