{"id":"epitizide","rwe":[],"tags":[{"label":"epitizide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C03EA03","category":"atc"},{"label":"Active","category":"status"},{"label":"Hypertensive disorder","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"epitizid","offLabel":[],"synonyms":["epitizide","epithiazide","epitizid"],"timeline":[],"approvals":[],"brandName":"Epitizid","ecosystem":[{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"epitizide","explanation":"Think of it like a key fitting into a lock. Epitizide is like the key, and the target is like the lock. When the key fits into the lock, it helps to turn off the signals that make blood pressure go up, which can help to lower blood pressure and treat hypertensive disorder.","oneSentence":"Epitizide is thought to work by interacting with a specific target to produce a therapeutic effect.","technicalDetail":"The exact mechanism of action of epitizide is unknown, but it is believed to involve interaction with a specific receptor or enzyme to produce a therapeutic effect."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Epitizide","title":"Epitizide","extract":"Epitizide is a diuretic. It is often combined with triamterene."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1031","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=epitizide","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Epitizide","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:03:30.919261","biosimilars":[],"competitors":[{"drugName":"hydrochlorothiazide","drugSlug":"hydrochlorothiazide","fdaApproval":"1959-02-12","patentExpiry":"Jan 23, 2044","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"trichlormethiazide","drugSlug":"trichlormethiazide","fdaApproval":"1960-03-09","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"chlortalidone","drugSlug":"chlortalidone","fdaApproval":"1960-04-07","relationship":"same-class"},{"drugName":"metolazone","drugSlug":"metolazone","fdaApproval":"1973-11-27","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"bendroflumethiazide","drugSlug":"bendroflumethiazide","fdaApproval":"1959-12-07","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"epitizide","indications":{"approved":[{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrochlorothiazide","brandName":"hydrochlorothiazide","genericName":"hydrochlorothiazide","approvalYear":"1959","relationship":"same-class"},{"drugId":"trichlormethiazide","brandName":"trichlormethiazide","genericName":"trichlormethiazide","approvalYear":"1960","relationship":"same-class"},{"drugId":"chlortalidone","brandName":"chlortalidone","genericName":"chlortalidone","approvalYear":"1960","relationship":"same-class"},{"drugId":"metolazone","brandName":"metolazone","genericName":"metolazone","approvalYear":"1973","relationship":"same-class"},{"drugId":"bendroflumethiazide","brandName":"bendroflumethiazide","genericName":"bendroflumethiazide","approvalYear":"1959","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"5B266B85J1","CHEBI":"CHEBI:135688","INN_ID":"1379","UMLSCUI":"C2700005","ChEMBL_ID":"CHEMBL2104605","KEGG_DRUG":"D04033","DRUGBANK_ID":"DB13989","PUBCHEM_CID":"15671"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C03EA03","allCodes":["C03EA03"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Epitizide is a small molecule diuretic. It is often used in combination with triamterene.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}