{"id":"epitiostanol","rwe":[{"pmid":"26657863","year":"2016","title":"Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.","finding":"","journal":"The Journal of clinical investigation","studyType":"Clinical Study"},{"pmid":"26247800","year":"2015","title":"Determination of mepitiostane metabolites in human urine by liquid chromatography/tandem mass spectrometry for sports drug testing.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"7641294","year":"1995","title":"Estrogen-depleted condition induces apoptosis of rat mammary cancer cells after entering the S-phase of the cell cycle.","finding":"","journal":"Cell structure and function","studyType":"Clinical Study"},{"pmid":"1488406","year":"1992","title":"Factors determining the intrinsic lymphatic partition rate of epitiostanol and mepitiostane.","finding":"","journal":"Pharmaceutical research","studyType":"Clinical Study"},{"pmid":"1796049","year":"1991","title":"Intrinsic lymphatic partition rate of mepitiostane, epitiostanol, and oleic acid absorbed from rat intestine.","finding":"","journal":"Pharmaceutical research","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"thiodrol","offLabel":[],"synonyms":["epitiostanol","epithiostanol","thiodrol"],"timeline":[],"approvals":[],"brandName":"Thiodrol","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Think of it like a traffic cop: Thiodrol blocks the road that leads to DHT, a hormone that can contribute to conditions like prostate enlargement and hair loss. By reducing DHT levels, Thiodrol may help alleviate symptoms associated with these conditions. This is a simplified explanation of a complex biochemical process.","oneSentence":"Thiodrol works by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a potent form of testosterone.","technicalDetail":"Thiodrol, also known as Epitiostanol, is a 17α-alkylated steroid that inhibits the enzyme 5α-reductase, which is responsible for converting testosterone to DHT. This inhibition leads to a decrease in DHT levels, which may contribute to its therapeutic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3181","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=EPITIOSTANOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:58:50.502208","biosimilars":[],"competitors":[],"genericName":"epitiostanol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"YE7586973L","CHEBI":"CHEBI:31546","INN_ID":"3530","UMLSCUI":"C0059457","ChEMBL_ID":"CHEMBL2106161","KEGG_DRUG":"D01265","PUBCHEM_CID":"443935","MESH_SUPPLEMENTAL_RECORD_UI":"C002976"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11,"therapeuticAreas":["Urology"],"biosimilarFilings":[],"recentPublications":[{"date":"2016 Jan","pmid":"26657863","title":"Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.","journal":"The Journal of clinical investigation"},{"date":"2015 Nov 10","pmid":"26247800","title":"Determination of mepitiostane metabolites in human urine by liquid chromatography/tandem mass spectrometry for sports drug testing.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"1995 Apr","pmid":"7641294","title":"Estrogen-depleted condition induces apoptosis of rat mammary cancer cells after entering the S-phase of the cell cycle.","journal":"Cell structure and function"},{"date":"1992 Dec","pmid":"1488406","title":"Factors determining the intrinsic lymphatic partition rate of epitiostanol and mepitiostane.","journal":"Pharmaceutical research"},{"date":"1991 Oct","pmid":"1796049","title":"Intrinsic lymphatic partition rate of mepitiostane, epitiostanol, and oleic acid absorbed from rat intestine.","journal":"Pharmaceutical research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Thiodrol, also known as Epitiostanol, is a small molecule modality with unknown drug class and target. Its commercial status is unclear, and it is not FDA approved for any indications. As a result, there is limited information available on its pharmacokinetic properties, such as half-life and bioavailability. Further research is needed to determine its efficacy and safety profile. It is currently owned by an unknown entity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}