{"id":"epirizole","rwe":[{"pmid":"38773695","year":"2024","title":"Ullmann-Type N-, S-, and O-Arylation Using a Well-Defined 7-Azaindole-N-oxide (7-AINO)-Based Copper(II) Catalyst: Scope and Application to Drug Synthesis.","finding":"","journal":"The Journal of organic chemistry","studyType":"Clinical Study"},{"pmid":"4087173","year":"1985","title":"Preparations of agglomerated crystals of polymorphic mixtures and a new complex of indomethacin-epirizole by the spherical crystallization technique.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"6357595","year":"1983","title":"[Controlled research on the use of epirizole in the therapy of rheumatoid arthritis].","finding":"","journal":"La Clinica terapeutica","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"mebron","offLabel":[],"synonyms":["methopyrimazole","epirizole","mepirizole","mebron"],"timeline":[],"approvals":[],"brandName":"Mebron","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like locks, and Mebron is a key that fits into those locks. When Mebron binds to the locks, it helps to turn off or turn on certain cellular processes that are involved in the disease it's meant to treat. This can help to restore balance to the body's normal functioning.","oneSentence":"Mebron works by binding to specific proteins or receptors in the body to produce a therapeutic effect.","technicalDetail":"Mebron is a small molecule that likely acts as a competitive inhibitor or agonist at its target, altering the normal functioning of the target protein or receptor to produce a therapeutic effect."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1029","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=EPIRIZOLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:58:45.884485","biosimilars":[],"competitors":[],"genericName":"epirizole","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"3B46O2FH8I","CHEBI":"CHEBI:31545","INN_ID":"2929","UMLSCUI":"C0014581","ChEMBL_ID":"CHEMBL1411693","KEGG_DRUG":"D01394","DRUGBANK_ID":"DB08991","PUBCHEM_CID":"3242","MESH_DESCRIPTOR_UI":"D004840"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Jun 7","pmid":"38773695","title":"Ullmann-Type N-, S-, and O-Arylation Using a Well-Defined 7-Azaindole-N-oxide (7-AINO)-Based Copper(II) Catalyst: Scope and Application to Drug Synthesis.","journal":"The Journal of organic chemistry"},{"date":"1985 Nov","pmid":"4087173","title":"Preparations of agglomerated crystals of polymorphic mixtures and a new complex of indomethacin-epirizole by the spherical crystallization technique.","journal":"Journal of pharmaceutical sciences"},{"date":"1983 Sep 30","pmid":"6357595","title":"[Controlled research on the use of epirizole in the therapy of rheumatoid arthritis].","journal":"La Clinica terapeutica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mebron is a small molecule with the synonyms DA-398, Epirizol, Epirizole, and Mebron.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}