{"id":"epinephrine-concentration-of-1-1000000","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Arrhythmias"}]},"_chembl":{"chemblId":"CHEMBL1256958","moleculeType":"Small molecule","molecularWeight":"333.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Epinephrine binds to alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors throughout the body. This activation increases cardiac contractility and heart rate (beta-1), causes vasoconstriction (alpha-1), and promotes bronchodilation (beta-2). The 1:1000000 concentration indicates an extremely dilute formulation, typically used for local anesthetic adjuvants or specific clinical applications requiring minimal systemic exposure.","oneSentence":"Epinephrine is an alpha and beta-adrenergic agonist that stimulates sympathetic nervous system receptors to increase heart rate, blood pressure, and bronchial airway diameter.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:09.876Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anaphylaxis (emergency treatment)"},{"name":"Cardiac arrest (ACLS protocol)"},{"name":"Severe hypotension"},{"name":"Adjuvant to local anesthetics (vasoconstrictor at 1:1000000 dilution)"}]},"trialDetails":[{"nctId":"NCT05822765","phase":"PHASE3","title":"Effect of Adrenaline Concentration on Intraoperative Hemodynamics of Liposuction Patients","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2023-05-01","conditions":"Intraoperative Hemodynamics, Liposuction","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Epinephrine concentration of 1:1000000","genericName":"Epinephrine concentration of 1:1000000","companyName":"Al-Azhar University","companyId":"al-azhar-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epinephrine is an alpha and beta-adrenergic agonist that stimulates sympathetic nervous system receptors to increase heart rate, blood pressure, and bronchial airway diameter. Used for Anaphylaxis (emergency treatment), Cardiac arrest (ACLS protocol), Severe hypotension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}