{"id":"epimestrol","rwe":[{"pmid":"2139451","year":"1990","title":"Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats.","finding":"","journal":"Journal of endocrinological investigation","studyType":"Clinical Study"},{"pmid":"2490913","year":"1989","title":"[Clinico-echographic study of the ovulatory phase, spontaneous and induced, conceptional and non conceptional cycles].","finding":"","journal":"Revista chilena de obstetricia y ginecologia","studyType":"Clinical Study"},{"pmid":"3140313","year":"1988","title":"[Effects of different methods of ovarian stimulation in adult rats].","finding":"","journal":"Revista espanola de fisiologia","studyType":"Clinical Study"},{"pmid":"3674548","year":"1987","title":"Radio-immunoassay of salivary progesterone for monitoring ovarian function in female infertility.","finding":"","journal":"Annales de biologie clinique","studyType":"Clinical Study"},{"pmid":"2944790","year":"1986","title":"[Treatment of hypothalamically-induced primary amenorrhea with epimestrol].","finding":"","journal":"Geburtshilfe und Frauenheilkunde","studyType":"Clinical Study"}],"tags":[{"label":"epimestrol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G03GB03","category":"atc"},{"label":"Active","category":"status"},{"label":"Estrogens","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"stimovul","offLabel":[],"synonyms":["epimestrol","stimovul"],"timeline":[],"approvals":[],"brandName":"Stimovul","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"epimestrol","explanation":"Imagine your body's cells have locks on them, and Stimovul is a key that fits into one of those locks. When it binds to the lock, it can either turn the lock on or off, depending on the type of lock and the key's shape. This interaction can affect how cells behave and respond to signals, but the exact details of how Stimovul works are still being studied.","oneSentence":"Stimovul is thought to work by interacting with a specific molecular target, although its exact mechanism of action is currently unknown.","technicalDetail":"Stimovul's mechanism of action is believed to involve binding to a specific receptor or enzyme, although the precise molecular details are currently unknown and require further investigation."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Epimestrol","title":"Epimestrol","extract":"Epimestrol, also known as 3-methoxy-17-epiestriol, is a synthetic, steroidal estrogen and an estrogen ether and prodrug of 17-epiestriol. It has been used as a component of ovulation induction in combination with gonadotropin-releasing hormone."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1026","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=EPIMESTROL","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Epimestrol","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:02:15.015158","biosimilars":[],"competitors":[{"drugName":"clomifene","drugSlug":"clomifene","fdaApproval":"1967-02-01","relationship":"same-class"}],"genericName":"epimestrol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clomifene","brandName":"clomifene","genericName":"clomifene","approvalYear":"1967","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"7IVE3SDZ38","CHEBI":"CHEBI:34738","INN_ID":"2739","UMLSCUI":"C0014561","ChEMBL_ID":"CHEMBL2106236","KEGG_DRUG":"D04021","DRUGBANK_ID":"DB13386","PUBCHEM_CID":"244809","MESH_DESCRIPTOR_UI":"D004836"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":43,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03GB03","allCodes":["G03GB03"]},"biosimilarFilings":[],"recentPublications":[{"date":"1990 Feb","pmid":"2139451","title":"Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats.","journal":"Journal of endocrinological investigation"},{"date":"1989","pmid":"2490913","title":"[Clinico-echographic study of the ovulatory phase, spontaneous and induced, conceptional and non conceptional cycles].","journal":"Revista chilena de obstetricia y ginecologia"},{"date":"1988 Mar","pmid":"3140313","title":"[Effects of different methods of ovarian stimulation in adult rats].","journal":"Revista espanola de fisiologia"},{"date":"1987","pmid":"3674548","title":"Radio-immunoassay of salivary progesterone for monitoring ovarian function in female infertility.","journal":"Annales de biologie clinique"},{"date":"1986 Jul","pmid":"2944790","title":"[Treatment of hypothalamically-induced primary amenorrhea with epimestrol].","journal":"Geburtshilfe und Frauenheilkunde"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Stimovul (EPIMESTROL) is a small molecule drug in the epimestrol class, but its target and exact mechanism of action are unknown. It is not clear if it is FDA-approved or commercially available. The drug's pharmacokinetic properties, such as half-life and bioavailability, are also unknown. As a result, there is limited information available on its approved indications, generic manufacturers, or patent status. Further research is needed to fully understand Stimovul's characteristics and clinical applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}