{"id":"epidural-analgesia-levobupivacaine0-125","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Hypotension"},{"rate":"5-15","effect":"Bradycardia"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-15","effect":"Urinary retention"},{"rate":"5-20","effect":"Pruritus"},{"rate":"<1","effect":"Neurological toxicity (at high doses)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. It reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and nerve impulse transmission. When administered epidurally, it produces anesthesia and analgesia in the lower body by blocking sensory and motor nerves in the epidural space.","oneSentence":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce regional anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:05.675Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Epidural anesthesia and analgesia for surgical procedures"},{"name":"Epidural analgesia for labor and delivery"},{"name":"Postoperative pain management via epidural administration"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Epidural analgesia"],"phase":"phase_3","status":"active","brandName":"Epidural analgesia:Levobupivacaine0,125%","genericName":"Epidural analgesia:Levobupivacaine0,125%","companyName":"Hospital General Universitario Elche","companyId":"hospital-general-universitario-elche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce regional anesthesia. Used for Epidural anesthesia and analgesia for surgical procedures, Epidural analgesia for labor and delivery, Postoperative pain management via epidural administration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}