{"id":"epidural-analgesia","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Epidural hematoma"},{"rate":null,"effect":"Infection/epidural abscess"}]},"_chembl":{"chemblId":"CHEMBL1290459","moleculeType":"Small molecule","molecularWeight":"328.16"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Epidural analgesia involves injection of local anesthetics and/or opioids into the epidural space, which surrounds the dura mater of the spinal cord. The medication diffuses across the dura to block nerve roots and spinal cord segments, providing regional anesthesia and analgesia without affecting consciousness. This technique is commonly used for perioperative pain management, labor analgesia, and chronic pain conditions.","oneSentence":"Epidural analgesia delivers pain-relieving medication directly into the epidural space around the spinal cord to block pain signals in a localized region.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:11:04.914Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative pain management"},{"name":"Labor analgesia"},{"name":"Postoperative pain relief"},{"name":"Chronic pain conditions"}]},"trialDetails":[{"nctId":"NCT07435077","phase":"PHASE4","title":"Examining Analgesic Synergy and Efficacy in Trauma Care","status":"NOT_YET_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2026-05","conditions":"Opioid Use Disorder","enrollment":282},{"nctId":"NCT07495566","phase":"","title":"Inflammatory Markers in Lumbar Radicular Pain Treated With PRF and 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University","startDate":"2023-10-20","conditions":"Video-assisted Thoracic Surgery","enrollment":252},{"nctId":"NCT04985695","phase":"NA","title":"Influence of Analgesic Technique on Post Operative Rehabilitation After Median Laparotomy","status":"RECRUITING","sponsor":"Centre Hospitalier Régional Metz-Thionville","startDate":"2021-10-11","conditions":"Laparotomy","enrollment":110},{"nctId":"NCT07281235","phase":"NA","title":"Perioperative Analgesia Using Ultrasound Guided Erector Spinae Block vs Ultrasound Guided Caudal Block for Pain Control in Children Aged 2-7 Years Undergoing Lower Abdominal Surgery","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2024-05-01","conditions":"Local Analgesia Via Infiltration, Caudal Epidural Anesthesia, Caudal Block","enrollment":60},{"nctId":"NCT07273136","phase":"NA","title":"Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery","status":"RECRUITING","sponsor":"Assiut University","startDate":"2025-12-10","conditions":"Subcostal, Lateral, Transversus Abdominis Plane Block","enrollment":50},{"nctId":"NCT07272018","phase":"","title":"Maternal and Fetal Clinical Significance of Hypotension Following Labor Epidural Analgesia","status":"NOT_YET_RECRUITING","sponsor":"The Chaim Sheba Medical Center","startDate":"2025-12","conditions":"Maternal Hypotension, Labor Epidural Analgesia, Fetal Heart Rate Abnormalities","enrollment":480},{"nctId":"NCT07264556","phase":"NA","title":"Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery","status":"RECRUITING","sponsor":"Fudan University","startDate":"2025-11-01","conditions":"Colorectal Cancer, Opioid-free Anesthesia, NETs","enrollment":90},{"nctId":"NCT07257744","phase":"","title":"Comparison of IV Analgesia, Thoracic Epidural Analgesia, and ESP Block for Chronic Pain After Open 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