{"id":"epiduo-tactuo","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Erythema"},{"rate":"15-25","effect":"Scaling/peeling"},{"rate":"15-20","effect":"Dryness"},{"rate":"10-15","effect":"Irritation"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL1265","moleculeType":"Small molecule","molecularWeight":"412.53"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize follicular keratinization and reduce comedone formation. Benzoyl peroxide provides antimicrobial activity against Cutibacterium acnes (formerly Propionibacterium acnes) and has mild keratolytic effects. Together, they address multiple pathogenic factors in acne development.","oneSentence":"Epiduo/Tactuo combines adapalene (a retinoid) and benzoyl peroxide to reduce acne by normalizing skin cell turnover and killing acne-causing bacteria.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:03.837Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT01474590","phase":"PHASE3","title":"Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2011-11","conditions":"Acne","enrollment":266}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Epiduo/Tactuo","genericName":"Epiduo/Tactuo","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epiduo/Tactuo combines adapalene (a retinoid) and benzoyl peroxide to reduce acne by normalizing skin cell turnover and killing acne-causing bacteria. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}