{"id":"epiduo-gel-right-face","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Erythema"},{"rate":"10-20","effect":"Dryness"},{"rate":"5-15","effect":"Peeling"},{"rate":"5-10","effect":"Irritation"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize follicular keratinization and reduce comedone formation. Benzoyl peroxide provides antimicrobial activity against Cutibacterium acnes (formerly Propionibacterium acnes) and has mild keratolytic effects. Together, these agents address multiple pathogenic factors in acne development.","oneSentence":"Epiduo combines adapalene (a retinoid) and benzoyl peroxide to reduce acne by normalizing skin cell turnover and killing acne-causing bacteria.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:45:34.737Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT02731105","phase":"PHASE4","title":"Pilot Study of Tolerability and Effectivity of Two Combination Topical Acne Products","status":"COMPLETED","sponsor":"GWT-TUD GmbH","startDate":"2015-02","conditions":"Acne Vulgaris","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Adapalen 0,1% and Benzoylperoxid 2,5%"],"phase":"marketed","status":"active","brandName":"Epiduo® Gel right face","genericName":"Epiduo® Gel right face","companyName":"GWT-TUD GmbH","companyId":"gwt-tud-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epiduo combines adapalene (a retinoid) and benzoyl peroxide to reduce acne by normalizing skin cell turnover and killing acne-causing bacteria. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}