{"id":"epidoxorubicine-docetaxel-ciclophosphamide-methotrexate-fluorouracile","safety":{"commonSideEffects":[{"rate":"20-40%","effect":"Neutropenia"},{"rate":"10-30%","effect":"Anemia"},{"rate":"5-20%","effect":"Thrombocytopenia"},{"rate":"50-80%","effect":"Nausea and vomiting"},{"rate":"20-50%","effect":"Diarrhea"},{"rate":"30-60%","effect":"Fatigue"},{"rate":"10-30%","effect":"Mucositis"},{"rate":"50-90%","effect":"Hair loss"}]},"_chembl":{"chemblId":"CHEMBL92","moleculeType":"Small molecule","molecularWeight":"807.89"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Epidoxorubicine's mechanism of action involves the intercalation of DNA strands, which inhibits the progression of topoisomerase II and induces apoptosis in cancer cells. Docetaxel's mechanism of action involves the stabilization of microtubules, preventing cell division and leading to cell death. Ciclophosphamide's mechanism of action involves the addition of an alkyl group to DNA, causing cross-linking and DNA damage. Methotrexate's mechanism of action involves the inhibition of dihydrofolate reductase, leading to a decrease in DNA synthesis and cell proliferation. Fluorouracile's mechanism of action involves the inhibition of thymidylate synthase, disrupting DNA synthesis and repair.","oneSentence":"Epidoxorubicine is an anthracycline antibiotic that intercalates DNA strands, thereby inhibiting the progression of topoisomerase II and inducing apoptosis in cancer cells. Docetaxel is a taxane that stabilizes microtubules, preventing cell division and leading to cell death. Ciclophosphamide is an alkylating agent that adds an alkyl group to DNA, causing cross-linking and DNA damage. Methotrexate is an antifolate that inhibits dihydrofolate reductase, leading to a decrease in DNA synthesis and cell proliferation. Fluorouracile is a thymidylate synthase inhibitor that disrupts DNA synthesis and repair.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:46:16.577Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic breast cancer"},{"name":"Metastatic non-small cell lung cancer"},{"name":"Metastatic ovarian cancer"},{"name":"Metastatic pancreatic cancer"}]},"trialDetails":[{"nctId":"NCT00174707","phase":"PHASE3","title":"Study of Docetaxel in Breast Cancer Patients","status":"COMPLETED","sponsor":"Sanofi","startDate":"1997-12","conditions":"Breast Neoplasms","enrollment":998}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"epidoxorubicine, docetaxel, ciclophosphamide, methotrexate, fluorouracile","genericName":"epidoxorubicine, docetaxel, ciclophosphamide, methotrexate, fluorouracile","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epidoxorubicine is an anthracycline antibiotic that intercalates DNA strands, thereby inhibiting the progression of topoisomerase II and inducing apoptosis in cancer cells. Docetaxel is a taxane that stabilizes microtubules, preventing cell division and leading to cell death. Ciclophosphamide is an alkylating agent that adds an alkyl group to DNA, causing cross-linking and DNA damage. Methotrexate is an antifolate that inhibits dihydrofolate reductase, leading to a decrease in DNA synthesis and cell proliferation. Fluorouracile is a thymidylate synthase inhibitor that disrupts DNA synthesis and repair. Used for Metastatic breast cancer, Metastatic non-small cell lung cancer, Metastatic ovarian cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}