{"id":"epidoxorubicine-ciclophosphamide-methotrexate-fluorouracile","safety":{"commonSideEffects":[{"rate":"20-40%","effect":"Myelosuppression"},{"rate":"5-15%","effect":"Cardiotoxicity"},{"rate":"50-70%","effect":"Nausea and vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Epidoxorubicine works by intercalating DNA strands, which prevents the enzyme topoisomerase II from unwinding DNA during replication, ultimately leading to cell death. This mechanism is specific to rapidly dividing cancer cells, making it an effective treatment for various types of cancer.","oneSentence":"Epidoxorubicine is an anthracycline antibiotic that intercalates DNA strands, thereby inhibiting the progression of topoisomerase II and inducing apoptosis in cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:46:25.415Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Breast cancer"},{"name":"Lung cancer"},{"name":"Lymphoma"}]},"trialDetails":[{"nctId":"NCT00174707","phase":"PHASE3","title":"Study of Docetaxel in Breast Cancer Patients","status":"COMPLETED","sponsor":"Sanofi","startDate":"1997-12","conditions":"Breast Neoplasms","enrollment":998}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"epidoxorubicine, ciclophosphamide, methotrexate, fluorouracile","genericName":"epidoxorubicine, ciclophosphamide, methotrexate, fluorouracile","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epidoxorubicine is an anthracycline antibiotic that intercalates DNA strands, thereby inhibiting the progression of topoisomerase II and inducing apoptosis in cancer cells. Used for Breast cancer, Lung cancer, Lymphoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}