{"id":"epi-off","safety":{"commonSideEffects":[{"rate":null,"effect":"Corneal haze"},{"rate":null,"effect":"Temporary vision reduction"},{"rate":null,"effect":"Dry eye"},{"rate":null,"effect":"Pain/discomfort during healing"}]},"_chembl":{"chemblId":"CHEMBL444360","moleculeType":"Small molecule","molecularWeight":"360.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The treatment involves instillation of riboflavin (vitamin B2) onto the cornea followed by exposure to UVA light, which creates cross-links between collagen fibers in the corneal stroma. This increases corneal rigidity and biomechanical strength, preventing further corneal ectasia and visual deterioration in progressive keratoconus and other corneal disorders.","oneSentence":"Epi-Off is a corneal cross-linking procedure that uses riboflavin and ultraviolet-A light to strengthen corneal collagen and halt progression of keratoconus.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:11:04.915Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Progressive keratoconus"},{"name":"Corneal ectasia post-refractive surgery"},{"name":"Pellucid marginal degeneration"}]},"trialDetails":[{"nctId":"NCT03663335","phase":"PHASE2","title":"Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2018-11-28","conditions":"Kidney Transplantation","enrollment":418},{"nctId":"NCT07245732","phase":"PHASE4","title":"Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares","status":"NOT_YET_RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2026-04","conditions":"Rheumatoid Arthritis (RA)","enrollment":220},{"nctId":"NCT07450547","phase":"PHASE2","title":"Phase 2 Study to Assess the Safety and Efficacy of ANG003","status":"NOT_YET_RECRUITING","sponsor":"Anagram Therapeutics, Inc.","startDate":"2026-04","conditions":"Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF)","enrollment":113},{"nctId":"NCT07418593","phase":"PHASE4","title":"THE MALABSORPTION BLOOD TEST TRIAL WILL HELP DETERMINE THE BENEFITS OF PANCREATIC ENZYME REPLACEMENT THERAPY IN PATIENTS WITH MILD TO MODERATE EXOCRINE PANCREATIC INSUFFICIENCY.","status":"RECRUITING","sponsor":"Anna Evans Phillips","startDate":"2026-03","conditions":"Chronic Pancreatitis, Recurrent Acute Pancreatitis, Exocrine Pancreatic Insufficiency","enrollment":80},{"nctId":"NCT07124910","phase":"PHASE3","title":"Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases","status":"RECRUITING","sponsor":"Woolfson Eye Institute","startDate":"2025-08-01","conditions":"Keratoconus, Ectasia of Cornea, Pellucid Marginal Corneal Degeneration","enrollment":485},{"nctId":"NCT07305948","phase":"","title":"Evaluation of a New MRI Technique to Reduce Breathing-Related Artifacts in Brain Imaging","status":"RECRUITING","sponsor":"Region Stockholm","startDate":"2026-01-05","conditions":"Brain Diseases","enrollment":100},{"nctId":"NCT07372911","phase":"NA","title":"PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus","status":"RECRUITING","sponsor":"Instituto de Oftalmología Fundación Conde de Valenciana","startDate":"2025-09-01","conditions":"Keratoconus","enrollment":50},{"nctId":"NCT06342544","phase":"PHASE3","title":"Immediate Corticosteroid Therapy and Rituximab to Prevent Generalization in Ocular Myasthenia: a PROBE Multicenter Open-label Randomized Controlled Trial.","status":"RECRUITING","sponsor":"Fondation Ophtalmologique Adolphe de Rothschild","startDate":"2025-04-29","conditions":"Ocular Myasthenia Gravis","enrollment":128},{"nctId":"NCT03292861","phase":"PHASE2","title":"The Effect and Safety Profile of Thymoglobulin® in Primary Cardiac Transplant Recipients","status":"ENROLLING_BY_INVITATION","sponsor":"Cedars-Sinai Medical Center","startDate":"2018-09-13","conditions":"Heart Transplantation","enrollment":60},{"nctId":"NCT06369922","phase":"NA","title":"TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.","status":"RECRUITING","sponsor":"University of Rochester","startDate":"2024-07-01","conditions":"Stress Incontinence Female, Urinary Incontinence, Urinary Incontinence,Stress","enrollment":100},{"nctId":"NCT03013998","phase":"PHASE1, PHASE2","title":"Study of Biomarker-Based Treatment of Acute Myeloid Leukemia","status":"RECRUITING","sponsor":"Beat AML, LLC","startDate":"2016-11","conditions":"Previously Untreated Relapsed Refractory Acute Myeloid Leukemia","enrollment":3000},{"nctId":"NCT01409161","phase":"PHASE2","title":"Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2011-10-05","conditions":"Acute Promyelocytic Leukemia With PML-RARA","enrollment":151},{"nctId":"NCT07280949","phase":"NA","title":"Posterior Transversus Abdominis Plane Block Combined With Sacral Multifidus Plane Block Versus Posterior Transversus Abdominis Plane Block for Laparoscopic Colorectal Surgery","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-01","conditions":"Anesthesia, Posterior Transversus Abdominis Plane Block, Sacral Multifidus Plane Block","enrollment":50},{"nctId":"NCT04477629","phase":"PHASE2","title":"Belatacept in De Novo Heart Transplantation","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2020-08-06","conditions":"Heart Transplantation","enrollment":12},{"nctId":"NCT06471348","phase":"NA","title":"Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine","status":"RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2025-08-15","conditions":"Post Operative Pain, Spinal Fusion","enrollment":128},{"nctId":"NCT07194538","phase":"","title":"One-Year Outcomes After Conventional vs Accelerated Epi-Off Corneal Cross-Linking in Progressive Keratoconus (Observational Cohort)","status":"COMPLETED","sponsor":"Clinical Hospital Centre Zagreb","startDate":"2021-05-09","conditions":"Keratoconus","enrollment":20},{"nctId":"NCT03959891","phase":"PHASE1","title":"AKT Inhibitor, Ipatasertib, With Endocrine and CDK 4/6 Inhibitor for Patients With Metastatic Breast Cancer (TAKTIC)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2019-05-30","conditions":"Breast Cancer","enrollment":77},{"nctId":"NCT05045157","phase":"NA","title":"Effectiveness of Percutaneous Pulley Release With Infiltration, Versus Infiltration Alone in Trigger Finders","status":"RECRUITING","sponsor":"Centre Hospitalier Departemental Vendee","startDate":"2022-05-31","conditions":"Trigger Finger","enrollment":90},{"nctId":"NCT07173907","phase":"","title":"Epi-on CuRV and Epi-off aCXL Protocols in the Management of Keratoconus","status":"COMPLETED","sponsor":"Gemini Eye Clinic","startDate":"2016-01-01","conditions":"Keratoconus","enrollment":135},{"nctId":"NCT04592744","phase":"PHASE4","title":"Angiotensin 2 for AKI After OLT","status":"ENROLLING_BY_INVITATION","sponsor":"University of California, Los Angeles","startDate":"2022-04-08","conditions":"Cirrhosis, Liver, End Stage Liver DIsease, Acute Kidney Injury","enrollment":30},{"nctId":"NCT05735522","phase":"NA","title":"Effectiveness of Magnetic Stimulation in the Treatment of Female UUI.","status":"COMPLETED","sponsor":"University Medical Centre Ljubljana","startDate":"2023-02-25","conditions":"Urinary Incontinence, Urinary Incontinence, Urge, Pelvic Floor Disorders","enrollment":70},{"nctId":"NCT04991961","phase":"","title":"Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism","status":"COMPLETED","sponsor":"Chongqing Medical University","startDate":"2020-09-15","conditions":"Hypertension, Primary Aldosteronism","enrollment":341},{"nctId":"NCT00476190","phase":"PHASE2","title":"ALL Adult Consortium Trial: Adult ALL Trial","status":"COMPLETED","sponsor":"Dana-Farber Cancer Institute","startDate":"2007-04","conditions":"Acute Lymphoblastic Leukemia","enrollment":112},{"nctId":"NCT05816798","phase":"PHASE2, PHASE3","title":"Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery","status":"RECRUITING","sponsor":"University of Nove de Julho","startDate":"2023-07-28","conditions":"Chronic Knee Pain, Obesity, Morbid","enrollment":62},{"nctId":"NCT06638931","phase":"PHASE2","title":"Agnostic Therapy in Rare Solid Tumors","status":"ACTIVE_NOT_RECRUITING","sponsor":"Instituto do Cancer do Estado de São Paulo","startDate":"2024-07-01","conditions":"Urachal Cancer, Parathyroid Carcinoma, Fibrolamellar Carcinoma","enrollment":28},{"nctId":"NCT01089933","phase":"NA","title":"Reducing Pain and Disability After Breast Cancer Surgery","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2009-09","conditions":"Breast Cancer, Chronic Pain","enrollment":129},{"nctId":"NCT05457647","phase":"NA","title":"Theranostic Guided Riboflavin/UV-A Corneal Cross-linking","status":"COMPLETED","sponsor":"Regensight","startDate":"2022-04-27","conditions":"Keratoconus","enrollment":50},{"nctId":"NCT05269888","phase":"","title":"Covid-19 Vaccine Immune Response in Multiple Sclerosis","status":"ACTIVE_NOT_RECRUITING","sponsor":"University Hospitals of North Midlands NHS Trust","startDate":"2022-02-16","conditions":"Multiple Sclerosis","enrollment":240},{"nctId":"NCT05870566","phase":"NA","title":"Pretreatment to Promote Graft Survival After Subsequent High-risk Corneal Transplantation [CrossCornealVision]","status":"RECRUITING","sponsor":"Claus Cursiefen","startDate":"2023-11-20","conditions":"Corneal Transplantation","enrollment":110},{"nctId":"NCT05427422","phase":"","title":"Stroke Recovery Research Based on EEG-fMRI","status":"COMPLETED","sponsor":"Xi'an Jiaotong University","startDate":"2022-06-30","conditions":"Motor Neuropathy","enrollment":147},{"nctId":"NCT03065465","phase":"NA","title":"Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage","status":"UNKNOWN","sponsor":"CURE Digestive Diseases Research Center","startDate":"2015-11-15","conditions":"Upper Gastrointestinal Hemorrhage","enrollment":65},{"nctId":"NCT06571084","phase":"","title":"New Screening and Diagnostic Cut-off Points of PA Patients","status":"RECRUITING","sponsor":"China National Center for Cardiovascular Diseases","startDate":"2024-01-04","conditions":"Primary Aldosteronism","enrollment":770},{"nctId":"NCT06549387","phase":"NA","title":"Topo-Pachymetric Customized Accelerated Epi-On Vs Accelerated Epi-Off Corneal Cross Linking in Keratoconus Management","status":"NOT_YET_RECRUITING","sponsor":"Kasr El Aini Hospital","startDate":"2024-08-15","conditions":"Amount of Corneal Flattening (Kmax Flattening), Change in the Endothelial Cell Count","enrollment":55},{"nctId":"NCT06097039","phase":"","title":"Fetuin-A, a Promising Serum Biomarker for Diagnosis of Non-Alcoholic Fatty Liver Disease","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2023-01-01","conditions":"Non-Alcoholic Fatty Liver Disease","enrollment":100},{"nctId":"NCT06128590","phase":"NA","title":"Photobiomodulation for Controlling Pre-Local Anesthetic Injection Pain","status":"COMPLETED","sponsor":"University of Nove de Julho","startDate":"2023-02-15","conditions":"Fear Needles","enrollment":50},{"nctId":"NCT04085237","phase":"NA","title":"ESP Block for Laparoscopic Nephrectomy Surgeries","status":"TERMINATED","sponsor":"McMaster University","startDate":"2020-01-04","conditions":"Kidney Cancer, Post-surgical Pain","enrollment":10},{"nctId":"NCT03990506","phase":"NA","title":"Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus","status":"COMPLETED","sponsor":"Umeå University","startDate":"2019-04-02","conditions":"Keratoconus, Corneal Crosslinking, Corneal Biomechanics","enrollment":32},{"nctId":"NCT00581334","phase":"","title":"Robotic-assisted Laparoscopic Sacrocolpopexy","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2007-05","conditions":"Pelvic Organ Prolapse","enrollment":20},{"nctId":"NCT04425447","phase":"NA","title":"Thoracic Interfascial Plane Block Versus Thoracic Paravertebral Block in Gynecomastia Surgery","status":"COMPLETED","sponsor":"Tanta University","startDate":"2020-06-20","conditions":"Gynecomastia, Thoracic Interfascial Plane Block, Thoracic Paravertebral Block","enrollment":90},{"nctId":"NCT05717673","phase":"","title":"Effect of Epi-Off Technique Corneal CXL On Endothelial Count by Specular Microscopy in Keratoconus Patients","status":"UNKNOWN","sponsor":"Heba Allah Nashaat Mohamed","startDate":"2023-01-01","conditions":"Keratoconus, Collagen","enrollment":30},{"nctId":"NCT03598166","phase":"NA","title":"Assessing the Effect of a Blood-based Colorectal Cancer Screening Test on Screening Adherence and Colonoscopy Completion","status":"COMPLETED","sponsor":"Peter S. Liang, MD MPH","startDate":"2018-10-11","conditions":"Colorectal Cancer","enrollment":359},{"nctId":"NCT01708538","phase":"PHASE3","title":"The Effects of Corneal Collagen Cross-linking","status":"UNKNOWN","sponsor":"Rush Eye Associates","startDate":"2012-10","conditions":"Corneal Ectasia Disorders Including Keratoconus","enrollment":30},{"nctId":"NCT03878914","phase":"PHASE4","title":"Steroid Sensitive Nephrotic Syndrome in Children","status":"TERMINATED","sponsor":"Wayne State University","startDate":"2019-08-06","conditions":"Nephrotic Syndrome in Children","enrollment":34},{"nctId":"NCT05330117","phase":"NA","title":"Nerve Stimulation Using a TENS to Provide Pain Relief During Surgery for Overactive Bladder","status":"COMPLETED","sponsor":"University of Rochester","startDate":"2020-12-14","conditions":"Urinary Incontinence, Overactive Bladder, Pain, Acute","enrollment":100},{"nctId":"NCT05284136","phase":"PHASE2, PHASE3","title":"Exclusion Diet vs corticosteroIds in patientS With activE Crohn's Disease","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2022-04-01","conditions":"Crohn Disease","enrollment":80},{"nctId":"NCT05060094","phase":"","title":"Comparison of Outcomes Between TransPRK and Off-flap Epi-LASIK","status":"COMPLETED","sponsor":"Wenzhou Medical University","startDate":"2016-03-01","conditions":"Refractive Surgery","enrollment":38},{"nctId":"NCT02198248","phase":"PHASE4","title":"Low-dose Glucocorticoid Vasculitis Induction Study","status":"UNKNOWN","sponsor":"Chiba University","startDate":"2014-10","conditions":"Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Microscopic Polyangiitis, Wegener Granulomatosis","enrollment":140},{"nctId":"NCT04693741","phase":"NA","title":"Xenografts With Platelet-rich Fibrin Versus Autogenous Bone in Alveolar Cleft Grafting","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2021-01","conditions":"Alveolar Cleft","enrollment":36},{"nctId":"NCT04207034","phase":"NA","title":"Effect of the Diode Laser on Bacteremia Associated With Periodontal Flap Surgery: A Clinico-Microbiological Study","status":"UNKNOWN","sponsor":"Krishnadevaraya College of Dental Sciences & Hospital","startDate":"2020-01-01","conditions":"Chronic Periodontitis","enrollment":10},{"nctId":"NCT02802514","phase":"PHASE4","title":"A Study Comparing the Effect of Albiglutide With Exenatide on Regional Brain Activity Related to Nausea in Healthy Subjects","status":"TERMINATED","sponsor":"GlaxoSmithKline","startDate":"2016-09-20","conditions":"Diabetes Mellitus","enrollment":5},{"nctId":"NCT04014400","phase":"NA","title":"Suprathel Versus Xeroform for the Management of Skin Graft Donor Sites","status":"TERMINATED","sponsor":"University of Colorado, Denver","startDate":"2019-07-07","conditions":"Burns, Skin Graft Complications, Skin; Deformity","enrollment":10},{"nctId":"NCT02328092","phase":"NA","title":"A Double-blind Randomized Clinical Trial on the Efficacy of Magnetic Sacral Roots Stimulation for the Treatment of NE","status":"COMPLETED","sponsor":"Assiut University","startDate":"2013-05","conditions":"Nocturnal Enuresis","enrollment":41},{"nctId":"NCT04064138","phase":"NA","title":"Analgesic Effect of Erector Spinea Plane Block Compared to Peritoneal Block in Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2019-07-01","conditions":"Laparoscopic Cholecystectomy","enrollment":52},{"nctId":"NCT01946880","phase":"PHASE2","title":"Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE)","status":"TERMINATED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2013-11-20","conditions":"Systemic Lupus Erythematosus, SLE","enrollment":102},{"nctId":"NCT01036594","phase":"PHASE2","title":"Ketoconazole and Dexamethasone in Prostate Cancer","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2009-12-11","conditions":"Prostate Cancer","enrollment":32},{"nctId":"NCT04291625","phase":"NA","title":"Evaluation of Intraoperative Lagophthalmos Formula","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2019-01-01","conditions":"Ptosis, Eyelid","enrollment":20},{"nctId":"NCT02979054","phase":"NA","title":"Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking","status":"COMPLETED","sponsor":"Laboratoires Thea","startDate":"2016-12","conditions":"Keratoconus","enrollment":157},{"nctId":"NCT03176667","phase":"NA","title":"Ultrasound Guided Erector Spinae Plane Block in Patients Undergoing VATS Lobectomy","status":"COMPLETED","sponsor":"McMaster University","startDate":"2018-12-06","conditions":"Post-operative Pain","enrollment":20},{"nctId":"NCT00624650","phase":"PHASE2","title":"Hemodynamics and Extravascular Lung Water in Acute Lung Injury","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2008-02","conditions":"Acute Lung Injury","enrollment":33},{"nctId":"NCT02044159","phase":"PHASE4","title":"Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study","status":"COMPLETED","sponsor":"Children's Hospital of Eastern Ontario","startDate":"2014-07","conditions":"Shock","enrollment":57},{"nctId":"NCT03879421","phase":"NA","title":"Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking.","status":"UNKNOWN","sponsor":"Reham Mahmoud Abdelrahman","startDate":"2016-10-01","conditions":"Keratoconus","enrollment":44},{"nctId":"NCT03858036","phase":"PHASE3","title":"Corneal Collagen Cross-Linking (CXL) Performed With \"Epi-ON\" Versus \"Epi-OFF\" in Eyes With Keratoconus and Other Corneal Ectatic Disorders","status":"UNKNOWN","sponsor":"Center for Sight, Sacramento, CA","startDate":"2019-03-08","conditions":"Keratoconus, Ectasia","enrollment":550},{"nctId":"NCT00453895","phase":"PHASE2","title":"Sunitinib in Refractory Adrenocortical Carcinoma","status":"COMPLETED","sponsor":"University of Wuerzburg","startDate":"2007-07","conditions":"Adrenocortical Carcinoma","enrollment":39},{"nctId":"NCT03753009","phase":"","title":"Iontophoretic Transepithelial Collagen Cross-linking Versus Epithelium-off Collagen Cross-linking in Pediatric Patients. Three Year Follow up.","status":"COMPLETED","sponsor":"Bambino Gesù Hospital and Research Institute","startDate":"2013-01-01","conditions":"Keratoconus","enrollment":28},{"nctId":"NCT03302390","phase":"","title":"Role of Chemokine and Chemokine Receptor in Psoriasis","status":"WITHDRAWN","sponsor":"University of California, Davis","startDate":"2017-04-17","conditions":"Psoriasis","enrollment":""},{"nctId":"NCT00805207","phase":"NA","title":"Sex Steroids, Sleep, and Metabolic Dysfunction in Women","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2007-09","conditions":"Polycystic Ovary Syndrome (PCOS), Obstructive Sleep Apnea, Obesity","enrollment":61},{"nctId":"NCT03598634","phase":"NA","title":"Epi Off Versus Epi on Corneal Collagen Cross-linking in Keratoconus Patients","status":"COMPLETED","sponsor":"University of Molise","startDate":"2014-06-01","conditions":"Keratoconus","enrollment":32},{"nctId":"NCT03080077","phase":"PHASE3","title":"Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia","status":"UNKNOWN","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2016-06","conditions":"Keratoconus, Ectasia","enrollment":8},{"nctId":"NCT03273309","phase":"NA","title":"Comparison of Vibratory Perineal Stimulus With Transvaginal Electrical Stimulation","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2017-06-01","conditions":"Urinary Incontinence","enrollment":42},{"nctId":"NCT01747070","phase":"NA","title":"Effect of Cranial Stimulation and Acupuncture on Pain, Functional Capability and Cerebral Function in Osteoarthritis","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2014-03","conditions":"Osteoarthritis, Knee, Chronic Pain","enrollment":60},{"nctId":"NCT02580240","phase":"NA","title":"Initiation of Hydrocortisone for the Treatment of Septic Shock","status":"COMPLETED","sponsor":"Northern Jiangsu People's Hospital","startDate":"2015-09","conditions":"Septic Shock","enrollment":118},{"nctId":"NCT00514982","phase":"PHASE2","title":"Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome","status":"WITHDRAWN","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2007-08-07","conditions":"Hermanski-Pudlak Syndrome, Colitis, Cytokines","enrollment":""},{"nctId":"NCT01688362","phase":"PHASE1","title":"Platelet Rich Plasma vs. Corticosteroid Injection in the Treatment of Partial Rotator Cuff Tears","status":"TERMINATED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2012-11","conditions":"Rotator Cuff Tear","enrollment":12},{"nctId":"NCT01209507","phase":"","title":"Prevalence Study of Adrenal Suppression After Corticosteroids During Chemotherapy","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2010-02","conditions":"Adrenal Suppression","enrollment":19},{"nctId":"NCT00445718","phase":"","title":"Natural History Study of Infants With Adrenal Masses Found on Prenatal and/or Neonatal Imaging","status":"COMPLETED","sponsor":"Children's Oncology Group","startDate":"2001-07","conditions":"Adrenocortical Carcinoma, Localized Resectable Neuroblastoma, Precancerous Condition","enrollment":97},{"nctId":"NCT01680861","phase":"PHASE3","title":"Tacrolimus/Everolimus Versus Tacrolimus/Enteric-Coated Mycophenolate Sodium","status":"COMPLETED","sponsor":"Gaetano Ciancio","startDate":"2012-11","conditions":"Transplant; Failure, Kidney","enrollment":32},{"nctId":"NCT02867176","phase":"PHASE4","title":"Pain Management in Corneal Collagen Crosslinking for Keratoconus","status":"COMPLETED","sponsor":"Instituto de Oftalmología Fundación Conde de Valenciana","startDate":"2016-01","conditions":"Pain","enrollment":25},{"nctId":"NCT02362321","phase":"PHASE4","title":"Role of Dexamethasone in the Conservative Treatment of Chronic Subdural Hematoma","status":"TERMINATED","sponsor":"CHU de Quebec-Universite Laval","startDate":"2007-01","conditions":"Hematoma, Subdural, Chronic","enrollment":20},{"nctId":"NCT01595386","phase":"NA","title":"Effect of Postop Steroids on Cardiovascular/Respiratory Function in Neonates Undergoing Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2012-04","conditions":"Heart Disease Congenital Complex","enrollment":40},{"nctId":"NCT00801632","phase":"PHASE2","title":"Combined Kidney and Bone Marrow Transplantation to Prevent Kidney Transplant Rejection","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2008-12","conditions":"Kidney Transplantation, Kidney Failure, Chronic","enrollment":5},{"nctId":"NCT02571842","phase":"PHASE4","title":"Rituximab in Recurrent IgA Nephropathy","status":"UNKNOWN","sponsor":"Chulalongkorn University","startDate":"2012-01","conditions":"Recurrent IgA Nephropathy","enrollment":30},{"nctId":"NCT02261662","phase":"NA","title":"Off-Label Use of Ribavirin in Management of Mucocutaneous Extrahepatic Manifestations of HCV Infection","status":"UNKNOWN","sponsor":"Tanta University","startDate":"2014-06","conditions":"Hepatitis C, Lichen Planus, Vasculitis","enrollment":30},{"nctId":"NCT00634920","phase":"PHASE4","title":"Evaluation of Early Conversion to Everolimus From Cyclosporine in de Novo Renal Transplant Recipients","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2008-03","conditions":"Renal Function","enrollment":204},{"nctId":"NCT02095730","phase":"PHASE3","title":"Corneal Cross-Linking Comparing Variables","status":"UNKNOWN","sponsor":"Crowd Health Research, LTD","startDate":"2014-05","conditions":"Unstable Corneas","enrollment":500},{"nctId":"NCT00645138","phase":"PHASE3","title":"Comparison of Paravertebral Block With General Anesthesia in Patients Undergoing Breast Cancer Surgery","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2008-04","conditions":"Breast Cancer","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":154,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Epi-Off","genericName":"Epi-Off","companyName":"Icahn School of Medicine at Mount Sinai","companyId":"icahn-school-of-medicine-at-mount-sinai","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epi-Off is a corneal cross-linking procedure that uses riboflavin and ultraviolet-A light to strengthen corneal collagen and halt progression of keratoconus. Used for Progressive keratoconus, Corneal ectasia post-refractive surgery, Pellucid marginal degeneration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}