{"id":"epervudine","rwe":[{"pmid":"7885687","year":"1995","title":"[Clinical comparison of two topical antiviral ointments in herpes].","finding":"","journal":"Orvosi hetilap","studyType":"Clinical Study"},{"pmid":"8379339","year":"1993","title":"[Pharmacokinetic studies of epervudine in rats using HPLC].","finding":"","journal":"Acta pharmaceutica Hungarica","studyType":"Clinical Study"},{"pmid":"8379338","year":"1993","title":"[Pharmacokinetic studies of 14C-labeled epervudine in rats].","finding":"","journal":"Acta pharmaceutica Hungarica","studyType":"Clinical Study"},{"pmid":"8379337","year":"1993","title":"[Analytical and stability studies carried out during the formulation development of Hevizos ointment].","finding":"","journal":"Acta pharmaceutica Hungarica","studyType":"Clinical Study"}],"tags":[{"label":"epervudine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"5-isopropyldeoxyuridine","offLabel":[],"synonyms":["epervudine","5-Isopropyldeoxyuridine"],"timeline":[],"approvals":[],"brandName":"5-Isopropyldeoxyuridine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"epervudine","explanation":"Think of EPERVUDINE like a roadblock for the virus. It prevents the virus from making copies of itself by blocking the enzyme that helps the virus replicate its genetic material. This can help slow down the spread of the virus in the body.","oneSentence":"EPERVUDINE works by inhibiting viral replication, specifically targeting the viral DNA polymerase.","technicalDetail":"EPERVUDINE is a nucleoside analog that acts as a chain terminator, inhibiting the viral DNA polymerase by being incorporated into the viral DNA and preventing further elongation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1023","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=EPERVUDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:02:00.349152","biosimilars":[],"competitors":[],"genericName":"epervudine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"3G05PH9FAS","CHEBI":"CHEBI:135111","INN_ID":"6439","UMLSCUI":"C2700002","ChEMBL_ID":"CHEMBL2104604","KEGG_DRUG":"D07899","PUBCHEM_CID":"512735"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"1995 Feb 19","pmid":"7885687","title":"[Clinical comparison of two topical antiviral ointments in herpes].","journal":"Orvosi hetilap"},{"date":"1993 Jul","pmid":"8379339","title":"[Pharmacokinetic studies of epervudine in rats using HPLC].","journal":"Acta pharmaceutica Hungarica"},{"date":"1993 Jul","pmid":"8379338","title":"[Pharmacokinetic studies of 14C-labeled epervudine in rats].","journal":"Acta pharmaceutica Hungarica"},{"date":"1993 Jul","pmid":"8379337","title":"[Analytical and stability studies carried out during the formulation development of Hevizos ointment].","journal":"Acta pharmaceutica Hungarica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"EPERVUDINE, also known as 5-Isopropyldeoxyuridine, is a small molecule drug in the epervudine class. Its exact target is unknown, but it is believed to work by inhibiting viral replication. EPERVUDINE has not been approved by the FDA for any indications. The commercial status of EPERVUDINE is unclear, with no information available on generic manufacturers or patent status. Further research is needed to determine the safety and efficacy of this compound.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}