{"id":"eperisone-hydrochloride-and-diclofenac-sodium","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL1034","moleculeType":"Small molecule","molecularWeight":"318.14"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Eperisone is a centrally-acting muscle relaxant that reduces muscle tone and spasticity through monoamine reuptake inhibition and alpha-adrenergic effects. Diclofenac is a non-selective COX inhibitor that reduces prostaglandin synthesis, providing anti-inflammatory and analgesic effects. Together, they target both the muscular and inflammatory components of musculoskeletal pain.","oneSentence":"This combination product uses eperisone as a muscle relaxant and diclofenac as an NSAID to reduce muscle tension and inflammation-related pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:11:04.536Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute musculoskeletal pain and muscle spasticity"},{"name":"Pain associated with muscle tension and inflammation"}]},"trialDetails":[{"nctId":"NCT01306318","phase":"NA","title":"A Clinical Study in Healthy Male Volunteers to Compare the Bioequivalence of Fixed Dose Combination of Eperisone Hydrochloride 50mg Plus Diclofenac Sodium 50mg as Capsule With Eperisone Hydrochloride 50mg and Diclofenac Sodium 50mg Tablets Under Fasting Conditions (Study 013-10)","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2011-02","conditions":"Healthy Volunteers","enrollment":24},{"nctId":"NCT01300312","phase":"PHASE3","title":"A Clinical Trial to Study the Effects of a Fixed Dose Combination of Diclofenac and Eperisone Hydrochloride With Plain Eperisone Hydrochloride in Patients With Low Back Pain","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2011-02","conditions":"Acute Musculoskeletal Spasm Due to Low Back Pain","enrollment":239}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Eperisone hydrochloride and Diclofenac sodium","genericName":"Eperisone hydrochloride and Diclofenac sodium","companyName":"Eisai Co., Ltd.","companyId":"eisai","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product uses eperisone as a muscle relaxant and diclofenac as an NSAID to reduce muscle tension and inflammation-related pain. Used for Acute musculoskeletal pain and muscle spasticity, Pain associated with muscle tension and inflammation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}