{"id":"epanolol","rwe":[{"pmid":"9554797","year":"1998","title":"Effects of epanolol, a selective beta1-blocker with intrinsic sympathomimetic activity, in patients with ischemic left ventricular dysfunction.","finding":"","journal":"Journal of cardiovascular pharmacology","studyType":"Clinical Study"},{"pmid":"7918133","year":"1994","title":"Acute systemic and antiischemic effects of epanolol in patients with coronary artery disease.","finding":"","journal":"Cardiovascular drugs and therapy","studyType":"Clinical Study"},{"pmid":"7915237","year":"1994","title":"The long-term effects of metoprolol and epanolol on tissue-type plasminogen activator and plasminogen activator inhibitor 1 in patients with ischaemic heart disease.","finding":"","journal":"European journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"8103354","year":"1993","title":"Do partial agonist beta-blockers have improved clinical utility?","finding":"","journal":"Cardiovascular drugs and therapy","studyType":"Clinical Study"},{"pmid":"8395198","year":"1993","title":"Long-term hemodynamic effects at rest and during exercise of newer antihypertensive agents and salt restriction in essential hypertension: review of epanolol, doxazosin, amlodipine, felodipine, diltiazem, lisinopril, dilevalol, carvedilol, and ketanserin.","finding":"","journal":"Cardiovascular drugs and therapy","studyType":"Clinical Study"}],"tags":[{"label":"epanolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C07AB10","category":"atc"},{"label":"Active","category":"status"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic beta-Antagonists","category":"pharmacology"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["epanolol","ICI-141,292"],"offLabel":[],"synonyms":["epanolol","ICI-141,292"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"epanolol","explanation":"Unfortunately, the exact mechanism of epanolol is not well understood, but it is thought to work by binding to a specific protein or receptor in the body, which then triggers a series of chemical reactions that ultimately lead to its therapeutic effect.","oneSentence":"Epanolol works by interacting with a specific target to produce a therapeutic effect.","technicalDetail":"The technical details of epanolol's mechanism of action are not available, but it is likely a competitive antagonist or agonist at a specific receptor or enzyme."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4467","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=EPANOLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:57:30.074018","biosimilars":[],"competitors":[{"drugName":"metoprolol","drugSlug":"metoprolol","fdaApproval":"1978-08-07","patentExpiry":"Jul 9, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"atenolol","drugSlug":"atenolol","fdaApproval":"1981-08-19","genericCount":22,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"acebutolol","drugSlug":"acebutolol","fdaApproval":"1984-12-28","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"betaxolol","drugSlug":"betaxolol","fdaApproval":"1985-08-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"bisoprolol","drugSlug":"bisoprolol","fdaApproval":"1992-07-31","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"esmolol","drugSlug":"esmolol","fdaApproval":"1986-12-31","patentExpiry":"Mar 15, 2033","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"nebivolol","drugSlug":"nebivolol","fdaApproval":"2007-12-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"epanolol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"metoprolol","brandName":"metoprolol","genericName":"metoprolol","approvalYear":"1978","relationship":"same-class"},{"drugId":"atenolol","brandName":"atenolol","genericName":"atenolol","approvalYear":"1981","relationship":"same-class"},{"drugId":"acebutolol","brandName":"acebutolol","genericName":"acebutolol","approvalYear":"1984","relationship":"same-class"},{"drugId":"betaxolol","brandName":"betaxolol","genericName":"betaxolol","approvalYear":"1985","relationship":"same-class"},{"drugId":"bisoprolol","brandName":"bisoprolol","genericName":"bisoprolol","approvalYear":"1992","relationship":"same-class"},{"drugId":"esmolol","brandName":"esmolol","genericName":"esmolol","approvalYear":"1986","relationship":"same-class"},{"drugId":"nebivolol","brandName":"nebivolol","genericName":"nebivolol","approvalYear":"2007","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"008150","UNII":"9KGC55KP6A","CHEBI":"CHEBI:4800","INN_ID":"5654","UMLSCUI":"C0116294","ChEMBL_ID":"CHEMBL87697","KEGG_DRUG":"D06646","DRUGBANK_ID":"DB13757","PUBCHEM_CID":"72014","MESH_SUPPLEMENTAL_RECORD_UI":"C038616"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"8%"},"publicationCount":43,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"C07AB10","allCodes":["C07AB10"]},"biosimilarFilings":[],"recentPublications":[{"date":"1998 Apr","pmid":"9554797","title":"Effects of epanolol, a selective beta1-blocker with intrinsic sympathomimetic activity, in patients with ischemic left ventricular dysfunction.","journal":"Journal of cardiovascular pharmacology"},{"date":"1994 Apr","pmid":"7918133","title":"Acute systemic and antiischemic effects of epanolol in patients with coronary artery disease.","journal":"Cardiovascular drugs and therapy"},{"date":"1994","pmid":"7915237","title":"The long-term effects of metoprolol and epanolol on tissue-type plasminogen activator and plasminogen activator inhibitor 1 in patients with ischaemic heart disease.","journal":"European journal of clinical pharmacology"},{"date":"1993 Jun","pmid":"8103354","title":"Do partial agonist beta-blockers have improved clinical utility?","journal":"Cardiovascular drugs and therapy"},{"date":"1993 Apr","pmid":"8395198","title":"Long-term hemodynamic effects at rest and during exercise of newer antihypertensive agents and salt restriction in essential hypertension: review of epanolol, doxazosin, amlodipine, felodipine, diltiazem, lisinopril, dilevalol, carvedilol, and ketanserin.","journal":"Cardiovascular drugs and therapy"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"EPANOLOL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epanolol is a small molecule drug in the epanolol class, but specific details about its target and mechanism of action are unknown. It is not clear if it is FDA approved or off-patent. As a result, there is limited information available about its commercial status or approved indications. Further research is needed to understand the pharmacology and clinical use of epanolol. Its bioavailability is 8%, but other pharmacokinetic parameters are unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}