{"id":"enteral-nutrition-alanyl-glutamin-dipeptiven","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal tolerance issues"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glutamine is a conditionally essential amino acid that becomes depleted during critical illness and serves as a primary fuel for enterocytes and immune cells. Alanyl-glutamine (Dipeptiven) delivers glutamine in a stable dipeptide form that can be added to enteral nutrition formulations, bypassing the instability of free glutamine and supporting intestinal mucosal integrity, immune cell proliferation, and overall protein metabolism during periods of metabolic stress.","oneSentence":"Alanyl-glutamine is a dipeptide that provides glutamine and alanine as substrates to support protein synthesis, immune function, and gut barrier integrity in critically ill or malnourished patients receiving enteral nutrition.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:11:01.112Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Enteral nutritional support in critically ill patients"},{"name":"Post-operative nutritional support"},{"name":"Patients at risk of glutamine depletion during metabolic stress"}]},"trialDetails":[{"nctId":"NCT01955772","phase":"PHASE3","title":"Randomized, Prospective, Multicenter Study to Compare Enteral Nutrition to Parenteral Nutrition as Feeding Support in Patients Presenting Malignant Hemopathy Who Underwent an Allogeneic Hematopoietic Stem Cell Transplantation.","status":"UNKNOWN","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2013-11","conditions":"Myeloablative Allo-SCT","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["All patients will received, whatever treatment arm, intravenous alanyl-glutamin, Dipeptiven which have AMM."],"phase":"phase_3","status":"active","brandName":"Enteral nutrition alanyl-glutamin, Dipeptiven","genericName":"Enteral nutrition alanyl-glutamin, Dipeptiven","companyName":"University Hospital, Clermont-Ferrand","companyId":"university-hospital-clermont-ferrand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alanyl-glutamine is a dipeptide that provides glutamine and alanine as substrates to support protein synthesis, immune function, and gut barrier integrity in critically ill or malnourished patients receiving enteral nutrition. Used for Enteral nutritional support in critically ill patients, Post-operative nutritional support, Patients at risk of glutamine depletion during metabolic stress.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}