{"id":"entecavir-fuzheng-huayu-tcm-granule","safety":{"commonSideEffects":[{"rate":null,"effect":"Lactic acidosis"},{"rate":null,"effect":"Hepatic flare"},{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Entecavir is a nucleoside reverse transcriptase inhibitor that directly suppresses HBV replication by blocking viral polymerase. The Fuzheng Huayu (扶正化瘀) TCM granule component is a traditional Chinese herbal formula designed to strengthen the body's resistance (Fuzheng) and promote blood circulation to resolve stasis (Huayu), theoretically supporting hepatic recovery and reducing liver fibrosis progression alongside antiviral therapy.","oneSentence":"This combination therapy uses entecavir to inhibit hepatitis B virus reverse transcriptase, combined with traditional Chinese medicine components to support liver function and reduce fibrosis.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:45:31.730Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic hepatitis B infection"},{"name":"Hepatitis B with liver fibrosis or cirrhosis"}]},"trialDetails":[{"nctId":"NCT02241616","phase":"PHASE4","title":"Traditional Chinese Medicine Combined With Entecavir to Treat Refractory Liver Fibrosis in Liver Cirrhosis Due to HBV","status":"UNKNOWN","sponsor":"ShuGuang Hospital","startDate":"2014-09","conditions":"Hepatitis B Virus Related Cirrhosis","enrollment":350}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Gan Ping","319 Recipe","FZHY"],"phase":"marketed","status":"active","brandName":"Entecavir+Fuzheng Huayu+TCM Granule","genericName":"Entecavir+Fuzheng Huayu+TCM Granule","companyName":"ShuGuang Hospital","companyId":"shuguang-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy uses entecavir to inhibit hepatitis B virus reverse transcriptase, combined with traditional Chinese medicine components to support liver function and reduce fibrosis. Used for Chronic hepatitis B infection, Hepatitis B with liver fibrosis or cirrhosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}