{"id":"entecavir-carvedilol-fuzheng-huayu","safety":{"commonSideEffects":[{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Lactic acidosis (entecavir-related)"},{"rate":null,"effect":"Gastrointestinal disturbance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Entecavir is a nucleoside reverse transcriptase inhibitor that suppresses hepatitis B virus replication. Carvedilol is a non-selective beta-blocker with alpha-blocking properties that reduces portal hypertension and cardiac stress. Fuzheng Huayu is a traditional Chinese medicine formula designed to promote liver regeneration and reduce hepatic fibrosis through immunomodulation and anti-inflammatory mechanisms.","oneSentence":"This combination therapy targets hepatitis B virus replication (entecavir), reduces cardiac workload and improves heart function (carvedilol), and enhances liver fibrosis resolution through traditional Chinese medicine principles (Fuzheng Huayu).","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:29:20.644Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic hepatitis B with cirrhosis or advanced fibrosis"},{"name":"Hepatitis B-related portal hypertension"}]},"trialDetails":[{"nctId":"NCT02945982","phase":"PHASE4","title":"Treatment of Moderate and Severe Cirrhotic Portal Hypertension Due to HBV With Fuzheng Huayu and Entecavir","status":"UNKNOWN","sponsor":"ShuGuang Hospital","startDate":"2018-04-05","conditions":"Portal Hypertension","enrollment":184}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":127,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Entecavir+Carvedilol+ Fuzheng Huayu","genericName":"Entecavir+Carvedilol+ Fuzheng Huayu","companyName":"ShuGuang Hospital","companyId":"shuguang-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy targets hepatitis B virus replication (entecavir), reduces cardiac workload and improves heart function (carvedilol), and enhances liver fibrosis resolution through traditional Chinese medicine principles (Fuzheng Huayu). Used for Chronic hepatitis B with cirrhosis or advanced fibrosis, Hepatitis B-related portal hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}