{"id":"enriched-ringer-s-lactate-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia (with prolonged use or renal impairment)"},{"rate":null,"effect":"Fluid overload / pulmonary edema"},{"rate":null,"effect":"Hyponatremia (with excessive administration)"},{"rate":null,"effect":"Phlebitis at infusion site"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a crystalloid solution containing sodium, potassium, calcium, chloride, and lactate ions in physiologically balanced concentrations. It is used for fluid resuscitation, maintenance of intravascular volume, and correction of electrolyte imbalances in clinical settings. The lactate component is metabolized by the liver to bicarbonate, providing mild alkalinizing effects.","oneSentence":"Enriched Ringer's lactate solution is an intravenous fluid replacement therapy that restores electrolyte balance and provides hydration to maintain cellular and circulatory homeostasis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:14.438Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fluid resuscitation and volume replacement in acute blood loss or dehydration"},{"name":"Maintenance fluid therapy in perioperative and critical care settings"},{"name":"Correction of electrolyte imbalances"}]},"trialDetails":[{"nctId":"NCT04922957","phase":"PHASE2","title":"A Phase 2b Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study, Evaluating Efficacy and Safety of Allocetra-OTS in Patients With Severe or Critical COVID-19 With Associated Acute Respiratory Distress Syndrome (ARDS)","status":"TERMINATED","sponsor":"Enlivex Therapeutics Ltd.","startDate":"2021-09-01","conditions":"Covid19","enrollment":12},{"nctId":"NCT04590053","phase":"PHASE2","title":"Allocetra-OTS in COVID-19, Phase II","status":"UNKNOWN","sponsor":"Hadassah Medical Organization","startDate":"2020-10-20","conditions":"Covid19","enrollment":24},{"nctId":"NCT04513470","phase":"PHASE1","title":"Allocetra-OTS in COVID-19","status":"UNKNOWN","sponsor":"Hadassah Medical Organization","startDate":"2020-08-01","conditions":"COVID-19","enrollment":5},{"nctId":"NCT03925857","phase":"PHASE1","title":"Prevention of Sepsis-related Organ Dysfunction With Allocetra-OTS","status":"COMPLETED","sponsor":"Enlivex Therapeutics Ltd.","startDate":"2019-01-27","conditions":"Organ Dysfunction Syndrome Sepsis","enrollment":10},{"nctId":"NCT02327611","phase":"PHASE4","title":"CUstodiol Versus RInger: whaT Is the Best Agent?","status":"COMPLETED","sponsor":"Scientific Institute San Raffaele","startDate":"2015-02","conditions":"Thoracoabdominal Aortic Aneurysms","enrollment":90},{"nctId":"NCT01334658","phase":"NA","title":"Study of Corneas Undergoing Balanced Salt Solution(BSS ®) Versus Glucose-bicarbonate-Ringer Lactate in Cataract Surgery","status":"COMPLETED","sponsor":"Grupo de Estudos em Oftalmologia Clínica e Cirúrgica","startDate":"2010-08","conditions":"Cataract","enrollment":64}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Enriched Ringer's lactate solution","genericName":"Enriched Ringer's lactate solution","companyName":"Scientific Institute San Raffaele","companyId":"scientific-institute-san-raffaele","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Enriched Ringer's lactate solution is an intravenous fluid replacement therapy that restores electrolyte balance and provides hydration to maintain cellular and circulatory homeostasis. Used for Fluid resuscitation and volume replacement in acute blood loss or dehydration, Maintenance fluid therapy in perioperative and critical care settings, Correction of electrolyte imbalances.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}