{"id":"enilconazole","rwe":[{"pmid":"41440659","year":"2025","title":"Effects of Insect Cuticular Compounds on Appressorium Formation and Metabolic Activity in Beauveria bassiana.","finding":"","journal":"Journal of fungi (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41132704","year":"2025","title":"Topical treatment of sinonasal aspergillosis with combined enilconazole infusion and frontal sinus deposition of clotrimazole cream in two cats.","finding":"","journal":"JFMS open reports","studyType":"Clinical Study"},{"pmid":"40574199","year":"2025","title":"Antifungal Action of Edible Coating Comprising Artichoke-Mediated Nanosilver and Chitosan Nanoparticles for Biocontrol of Citrus Blue Mold.","finding":"","journal":"Polymers","studyType":"Clinical Study"},{"pmid":"39900467","year":"2025","title":"Drug-resistance genes and antifungal susceptibility of Trichophyton verrucosum variants isolated from bovine skin lesions and farm environments.","finding":"","journal":"Medical mycology","studyType":"Clinical Study"},{"pmid":"39863777","year":"2025","title":"Therapeutic alternatives for sporotrichosis induced by wild-type and non-wild-type Sporothrix schenckii through in vitro and in vivo assessment of enilconazole, isavuconazole, posaconazole, and terbinafine.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"}],"tags":[{"label":"enilconazole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Indoleamine 2,3-dioxygenase 1","category":"target"},{"label":"IDO1","category":"gene"},{"label":"Active","category":"status"},{"label":"Fungicides, Industrial","category":"pharmacology"},{"label":"Pesticides","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bromazil","offLabel":[],"synonyms":["enilconazole","imazalil","bromazil","deccozil","imazalil phosphate","imazalil sulfate","imazalil mononitrate"],"timeline":[],"aiSummary":"Bromazil is a small molecule with the synonyms AMOLDEN MP 100, BROMAZIL, CGA-41333, CLINAFARM, DECCOSIL, and DECCOZIL. Its exact mechanism and indications are not specified in the provided information.","approvals":[],"brandName":"Bromazil","ecosystem":[],"mechanism":{"target":"Indoleamine 2,3-dioxygenase 1","targets":[{"gene":"IDO1","source":"DrugCentral","target":"Indoleamine 2,3-dioxygenase 1","protein":"Indoleamine 2,3-dioxygenase 1"}],"modality":"Small Molecule","drugClass":"enilconazole","explanation":"Think of tryptophan as a building block for the body's natural chemicals. Indoleamine 2,3-dioxygenase 1 is like a demolition crew that breaks down tryptophan. Enilconazole stops this demolition crew from working, allowing tryptophan to be used for other important functions.","oneSentence":"Enilconazole works by inhibiting the enzyme indoleamine 2,3-dioxygenase 1, which is involved in the breakdown of tryptophan.","technicalDetail":"Enilconazole acts as a competitive inhibitor of indoleamine 2,3-dioxygenase 1, specifically binding to the enzyme's active site and preventing the breakdown of tryptophan into 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