{"id":"engineered-hb-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Myalgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This vaccine contains modified or recombinant hepatitis B surface antigen (HBsAg) designed to elicit stronger cellular and humoral immune responses compared to conventional HB vaccines. The engineering approach aims to improve immunogenicity and protective efficacy, potentially through optimization of antigen structure, formulation, or delivery to enhance B cell and T cell activation against hepatitis B virus.","oneSentence":"An engineered hepatitis B vaccine that stimulates immune responses to prevent hepatitis B virus infection through enhanced antigen presentation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:32:37.675Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of hepatitis B virus infection"}]},"trialDetails":[{"nctId":"NCT00939068","phase":"PHASE4","title":"Efficacy and Safety Study of Telbivudine to Prevent Perinatal Transmission","status":"UNKNOWN","sponsor":"Southeast University, China","startDate":"2008-02","conditions":"Chronic Hepatitis B, Gestation","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["control group"],"phase":"marketed","status":"active","brandName":"engineered HB vaccine","genericName":"engineered HB vaccine","companyName":"Southeast University, China","companyId":"southeast-university-china","modality":"Biologic","firstApprovalDate":"","aiSummary":"An engineered hepatitis B vaccine that stimulates immune responses to prevent hepatitis B virus infection through enhanced antigen presentation. Used for Prevention of hepatitis B virus infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}