{"id":"engerix-b-kinder","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Injection site pain, redness, or swelling"},{"rate":"1-6","effect":"Fever"},{"rate":"5-15","effect":"Irritability"},{"rate":"1-5","effect":"Fatigue"},{"rate":"1-3","effect":"Loss of appetite"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains recombinant hepatitis B surface antigen (HBsAg) produced in yeast cells. When administered, it triggers both humoral and cellular immune responses, leading to the production of protective antibodies (anti-HBs) and memory B cells. This immunological memory enables rapid immune response upon exposure to the actual hepatitis B virus, preventing infection and disease.","oneSentence":"Engerix-B Kinder is a hepatitis B vaccine that stimulates the immune system to produce antibodies against hepatitis B surface antigen, providing protection against hepatitis B infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:29:16.641Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Active immunization against hepatitis B infection in infants and children"}]},"trialDetails":[{"nctId":"NCT02798952","phase":"PHASE4","title":"A Study to Evaluate Persistence of Hepatitis B Antibodies, Immunogenicity and Safety of Engerix™-B Kinder Challenge Dose, in Adolescents Vaccinated With Four Doses of Infanrix™ Hexa During Infancy","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-08-23","conditions":"Hepatitis B","enrollment":302},{"nctId":"NCT00984139","phase":"PHASE4","title":"Persistence of Immunity Against Hepatitis B in 12-13 Year Old Adolescents After Infant Hepatitis B Vaccination","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-10-12","conditions":"Hepatitis B","enrollment":306},{"nctId":"NCT01847430","phase":"PHASE4","title":"Evaluation of the Long-term Persistence of Immunity to Hepatitis B, in Adolescents Vaccinated in Infancy With Engerix™-B Kinder","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-07-19","conditions":"Hepatitis B","enrollment":303},{"nctId":"NCT00519649","phase":"PHASE4","title":"Long-term Persistence of Immunity Against Hepatitis B in 7-8 Years Old Children After Hepatitis B Vaccination.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-08-31","conditions":"Hepatitis B Vaccine","enrollment":301},{"nctId":"NCT01333813","phase":"PHASE4","title":"Hepatitis B Antibody Persistence and Immune Response to Hepatitis B Vaccine Challenge in Previously Vaccinated Children","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2011-04-26","conditions":"Hepatitis B","enrollment":300},{"nctId":"NCT02052661","phase":"PHASE4","title":"This Study Aims to Determine the Long-term Persistence of Antibodies Against Hepatitis B and to Evaluate the Immunogenicity and Safety of Hepatitis B Vaccine in Adolescents Vaccinated in Infancy With Infanrix™ Hexa","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-02-18","conditions":"Hepatitis B","enrollment":301},{"nctId":"NCT00411697","phase":"PHASE4","title":"Persistence of Hepatitis B Antibody Levels & Immune Response to a Hepatitis B Vaccine Challenge","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-12","conditions":"Hepatitis B","enrollment":301},{"nctId":"NCT00355654","phase":"PHASE3","title":"Study to Compare Booster Vaccination With Pediacel® to Infanrix® Hexa When Both Are Co-Administered With Prevenar®","status":"COMPLETED","sponsor":"Sanofi Pasteur, a Sanofi Company","startDate":"2006-09","conditions":"Infant, Healthy","enrollment":847}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["HBV vaccine","Engerix™-B"],"phase":"marketed","status":"active","brandName":"Engerix-B Kinder","genericName":"Engerix-B Kinder","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"Engerix-B Kinder is a vaccine used to prevent Hepatitis B. It is administered to adolescents who were previously vaccinated against Hepatitis B as infants.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}