{"id":"eng-120-g-ee-15-g-intravaginal-ring","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vaginal irritation or discomfort"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Breakthrough bleeding or spotting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The combination of etonogestrel and ethinyl estradiol works synergistically to suppress the luteinizing hormone (LH) surge needed for ovulation, while also thickening cervical mucus and altering the endometrium to prevent fertilization and implantation. The intravaginal ring formulation provides sustained, controlled release of both hormones over a 3-week cycle, offering a non-daily contraceptive option with improved compliance compared to oral formulations.","oneSentence":"This intravaginal ring releases etonogestrel (a progestin) and ethinyl estradiol (an estrogen) to prevent ovulation and provide contraception.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:10:58.132Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception in women of reproductive age"}]},"trialDetails":[{"nctId":"NCT01277211","phase":"PHASE3","title":"A Study to Evaluate the Effectiveness of NuvaRing® to Prevent Pregnancies in Chinese Women (P06450)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2011-09-19","conditions":"Contraception","enrollment":983}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NuvaRing"],"phase":"phase_3","status":"active","brandName":"ENG 120 µg + EE 15 µg intravaginal ring","genericName":"ENG 120 µg + EE 15 µg intravaginal ring","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This intravaginal ring releases etonogestrel (a progestin) and ethinyl estradiol (an estrogen) to prevent ovulation and provide contraception. Used for Contraception in women of reproductive age.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}