{"id":"endodontic-treatment-using-vitapex","safety":{"commonSideEffects":[{"rate":null,"effect":"Periapical inflammation"},{"rate":null,"effect":"Allergic reaction to iodoform"},{"rate":null,"effect":"Extrusion beyond apex"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitapex is a premeasured, injectable calcium hydroxide paste combined with iodoform that is delivered through a plastic carrier into the root canal system. The calcium hydroxide component provides alkaline pH to neutralize bacterial acids and promote periapical healing, while the iodoform provides radiopacity and additional antimicrobial properties. The system allows for precise, three-dimensional obturation of the root canal space.","oneSentence":"Vitapex is a calcium hydroxide-based root canal filling material that provides antimicrobial action and promotes healing in endodontic treatment.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:10:56.114Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Root canal treatment and obturation in primary and permanent teeth"},{"name":"Endodontic therapy for infected or necrotic pulp"}]},"trialDetails":[{"nctId":"NCT02216942","phase":"PHASE3","title":"Endodontic Treatment of Necrotic Primary Teeth With Guedes Pinto Paste: A Randomized Clinical Trial","status":"COMPLETED","sponsor":"Fausto Medeiros Mendes","startDate":"2015-01","conditions":"Endodontic Treatment of Primary Teeth","enrollment":104},{"nctId":"NCT02887456","phase":"PHASE2","title":"Endodontic Treatment of Primary Teeth Using Mineral Trioxide Aggregate Paste","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2016-09","conditions":"Teeth, Endodontically-Treated","enrollment":39}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":52,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Endodontic treatment using Vitapex","genericName":"Endodontic treatment using Vitapex","companyName":"Fausto Medeiros Mendes","companyId":"fausto-medeiros-mendes","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vitapex is a calcium hydroxide-based root canal filling material that provides antimicrobial action and promotes healing in endodontic treatment. Used for Root canal treatment and obturation in primary and permanent teeth, Endodontic therapy for infected or necrotic pulp.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}