{"id":"encequidar-tablet","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL4594298","moleculeType":"Small molecule","molecularWeight":"688.74"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By inhibiting P-glycoprotein, Encequidar increases the bioavailability of co-administered chemotherapeutic agents, thereby enhancing their therapeutic efficacy. This mechanism is particularly relevant in the context of cancer treatment, where P-glycoprotein can act as a barrier to drug entry into cancer cells.","oneSentence":"Encequidar is a potent and selective inhibitor of P-glycoprotein.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:10:49.356Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of cancer, particularly in combination with chemotherapeutic agents"}]},"trialDetails":[{"nctId":"NCT06835400","phase":"PHASE3","title":"Oral Paclitaxel + Encequidar vs IV Paclitaxel in Treatment of HER2 Negative Metastatic Breast Cancer","status":"NOT_YET_RECRUITING","sponsor":"Health Hope Pharma","startDate":"2025-09","conditions":"Metastatic Breast Cancer","enrollment":340}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Encequidar tablet","genericName":"Encequidar tablet","companyName":"Health Hope Pharma","companyId":"health-hope-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Encequidar is a potent and selective inhibitor of P-glycoprotein. Used for Treatment of cancer, particularly in combination with chemotherapeutic agents.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}