{"id":"enbucrilate","rwe":[{"pmid":"37387411","year":"2024","title":"[Recurrent Bacteremia after Cyanoacrylate Sclerotherapy of Ectopic Duodenal Varices].","finding":"","journal":"Acta medica portuguesa","studyType":"Clinical Study"},{"pmid":"36596751","year":"2022","title":"A vertically split fracture of the marginal tubercle of the zygoma in a 3-year-old boy: a case report.","finding":"","journal":"Archives of craniofacial surgery","studyType":"Clinical Study"},{"pmid":"34626937","year":"2021","title":"Injectable Mussel-Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration.","finding":"","journal":"Biomaterials","studyType":"Clinical Study"},{"pmid":"33501598","year":"2021","title":"Portal vein embolization with N-butyl cyanoacrylate glue is superior to other materials: a systematic review and meta-analysis.","finding":"","journal":"European radiology","studyType":"Clinical Study"},{"pmid":"33187154","year":"2020","title":"Description, Staging and Quantification of Pulmonary Artery Angiophagy in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension.","finding":"","journal":"Biomedicines","studyType":"Clinical Study"}],"tags":[{"label":"enbucrilate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_3","safety":{"safetySignals":[{"llr":202.68,"date":"","count":45,"signal":"Product use in unapproved indication","source":"DrugCentral FAERS","actionTaken":"Reported 45 times (LLR=203)"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"indermil","offLabel":[],"synonyms":["n-butyl cyanoacrylate","butyl cyanoacrylate","butyl alpha-cyanoacrylate","enbucrilate","histacryl blue","indermil","n-Butyl 2-cyanoacrylate"],"timeline":[],"aiSummary":"Indermil (Enbucrilate) is a small molecule enbucrilate drug used for its adhesive properties in wound closure and skin closure. It works by forming a strong bond between the skin and the wound, promoting healing and reducing the risk of infection. The commercial status of Indermil is not publicly available, and it is not clear if it is patented or available as a generic product. Indermil is used to treat skin wounds and closures, but its exact target and mechanism of action are not well-documented. As a result, key safety considerations and pharmacokinetic properties are not well-established.","approvals":[],"brandName":"Indermil","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"enbucrilate","explanation":"Imagine a strong glue that helps hold your skin together while it heals. Indermil is like that glue, but it's a special medicine that helps your skin close up and heal faster. It's not something that gets absorbed into your body, but rather stays on the surface to do its job.","oneSentence":"Indermil works by forming a strong adhesive bond between the skin and the wound.","technicalDetail":"Enbucrilate is a synthetic polymer that forms a strong covalent bond with the skin, creating a durable and impermeable barrier that promotes wound closure and healing."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3056","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ENBUCRILATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ENBUCRILATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:55:53.243211","biosimilars":[],"competitors":[],"genericName":"enbucrilate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07491276","phase":"NA","title":"Efficacy of Using Knotless Barbed Suture vs N-Butyl Cyanoacrylate Glue Tissue Adhesive for Closure of Intraoral Surgical Incisions","status":"ACTIVE_NOT_RECRUITING","sponsor":"Future University in 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Hernia"],"enrollment":370,"completionDate":"2017-01"},{"nctId":"NCT02778802","phase":"","title":"Pulmonary Hemodynamics in Patients With Severe Emphysema Pre and Post BLVR","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2016-06","conditions":["Pulmonary Hypertension","Chronic Obstructive Lung Disease"],"enrollment":20,"completionDate":"2017-05"},{"nctId":"NCT02932033","phase":"NA","title":"Trial Comparing Tack Versus Histoacryl Mesh Fixation After Endoscopic TEP(Total Extraperitoneal) Repair for Bilateral Inguinal Hernia","status":"UNKNOWN","sponsor":"Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation","startDate":"2016-11","conditions":["Inguinal Hernia"],"enrollment":100,"completionDate":""},{"nctId":"NCT02945930","phase":"","title":"Study the Safety and Efficacy of \"Compont Medical Glue\" in the Treatment of Esophagogastric Varices","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2016-09","conditions":["Esophageal and Gastric 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