{"id":"enalapril-folic-acid","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Cough"},{"rate":"5-10","effect":"Dizziness"},{"rate":"3-5","effect":"Fatigue"},{"rate":"2-5","effect":"Hyperkalemia"},{"rate":"<1","effect":"Angioedema"}]},"_chembl":{"chemblId":"CHEMBL578","moleculeType":"Small molecule","molecularWeight":"376.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Enalapril is an ACE inhibitor that blocks the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Folic acid is included as a B-vitamin supplement to support overall cardiovascular health and potentially mitigate homocysteine elevation, which can be a risk factor in hypertension management. This combination addresses both the primary antihypertensive effect and nutritional support.","oneSentence":"Enalapril inhibits angiotensin-converting enzyme (ACE) to reduce blood pressure, while folic acid supplementation supports cardiovascular health and may reduce homocysteine levels.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:23.087Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Heart failure"},{"name":"Post-myocardial infarction"}]},"trialDetails":[{"nctId":"NCT04952051","phase":"PHASE3","title":"Enalapril Folic Acid Tablets Combined With CCB or Diuretic to Prevent Stroke in Patients With Type H Hypertension","status":"COMPLETED","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2014-07-01","conditions":"Hypertension","enrollment":1000},{"nctId":"NCT03259399","phase":"","title":"A Pharmacogenomics Study of Safety and Efficacy of Enalapril or Enalapril-Folic Acid Therapy in Hypertensive Patients.","status":"UNKNOWN","sponsor":"Cui Yimin","startDate":"2017-08-16","conditions":"Enalapril Adverse Reaction, Pharmacogenomics, Stroke","enrollment":2200},{"nctId":"NCT02575092","phase":"PHASE2, PHASE3","title":"The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment","status":"COMPLETED","sponsor":"Fuling Central Hospital of Chongqing City","startDate":"2015-11-01","conditions":"Homocysteine, Coronary Disease, Angioplasty,Balloon,Coronary","enrollment":4000},{"nctId":"NCT03472508","phase":"PHASE4","title":"H-Type Hypertension Precision Medicine Trial","status":"UNKNOWN","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2018-03-20","conditions":"Hypertension","enrollment":3600},{"nctId":"NCT02817503","phase":"PHASE4","title":"Feasibility Study of the Intensive Systolic Blood Pressure Control","status":"UNKNOWN","sponsor":"Second Affiliated Hospital of Nanchang University","startDate":"2015-12","conditions":"Hypertension, Hyperhomocysteinemia","enrollment":100},{"nctId":"NCT01871740","phase":"PHASE4","title":"CSPPT- Chronic Kidney Diseases Study","status":"WITHDRAWN","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2008-05","conditions":"Hypertension, Hyperhomocysteinemia","enrollment":""},{"nctId":"NCT00794885","phase":"PHASE4","title":"China Stroke Primary Prevention Trial","status":"COMPLETED","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2008-05","conditions":"Primary Hypertension","enrollment":20702},{"nctId":"NCT00520247","phase":"PHASE2","title":"Effect of Enalapril Plus Folic Acid on Blood Pressure and Glycometabolism","status":"COMPLETED","sponsor":"Anhui Medical University","startDate":"2005-09","conditions":"Plasma Total Homocysteine Level, Blood Pressure","enrollment":443}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Enalapril Maleate and Folic Acid Tablet"],"phase":"marketed","status":"active","brandName":"Enalapril/folic acid","genericName":"Enalapril/folic acid","companyName":"Shenzhen Ausa Pharmed Co.,Ltd","companyId":"shenzhen-ausa-pharmed-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Enalapril inhibits angiotensin-converting enzyme (ACE) to reduce blood pressure, while folic acid supplementation supports cardiovascular health and may reduce homocysteine levels. Used for Hypertension, Heart failure, Post-myocardial infarction.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}