{"id":"emono","safety":{"commonSideEffects":[{"rate":null,"effect":"Methemoglobinemia"},{"rate":null,"effect":"Nitrogen dioxide exposure toxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Air Liquide Santé International's EMONO appears to be a therapeutic gas product, potentially containing nitric oxide or similar gaseous agents that act on vascular endothelium to promote vasodilation and improve gas exchange. The exact mechanism requires confirmation from clinical trial data, but therapeutic gases in this class typically work by modulating nitric oxide signaling pathways or improving oxygen delivery to tissues.","oneSentence":"EMONO is a medical gas mixture (likely nitric oxide-based) designed to improve oxygenation and reduce pulmonary hypertension in critically ill patients.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:10:42.169Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute respiratory distress syndrome (ARDS) or severe hypoxemia (Phase 3 indication pending confirmation)"}]},"trialDetails":[{"nctId":"NCT06928740","phase":"NA","title":"Efficacy on Anxiety of the Digital Music Application Versus Equimolar Mixture of Oxygen and Nitrous Oxide in Patients Receiving CT-guided Lumbar Infiltration","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2025-10-21","conditions":"Low Back Pain, Anxiety","enrollment":128},{"nctId":"NCT07299006","phase":"NA","title":"Evaluation of Paro, a Therapeutic Assistance Robot in Analgesic Management During the Placement of a Peripheral Intravenous Line in Infants and Children.","status":"NOT_YET_RECRUITING","sponsor":"Fondation Lenval","startDate":"2026-01-15","conditions":"Pain Management","enrollment":120},{"nctId":"NCT05007028","phase":"NA","title":"Nitrous Oxide for Late-Life Depression - PROTO-BRAIN","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2021-11-16","conditions":"Late-Life Depression, Resistant Depression, Treatment","enrollment":60},{"nctId":"NCT06382389","phase":"PHASE2","title":"Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial-","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Tours","startDate":"2024-06","conditions":"Depression, Neurocognitive Disorders","enrollment":96},{"nctId":"NCT05435118","phase":"NA","title":"Use of the Equimolar Mixture of Oxide Nitrous and Oxygen (EMONO) Associated With Audiovisuals in Children","status":"COMPLETED","sponsor":"Azienda Socio Sanitaria Territoriale di Lodi","startDate":"2023-08-17","conditions":"Pain, Acute, Child, Only, Nurse's Role","enrollment":120},{"nctId":"NCT04076748","phase":"PHASE3","title":"Evaluation of the Efficacy of Intra-nasal Sufentanil for Analgesia of Vaso-occlusive Crisis in Sickle-cell Adults.","status":"UNKNOWN","sponsor":"University Hospital, Bordeaux","startDate":"2021-07-20","conditions":"Sickle Cell Crisis","enrollment":196},{"nctId":"NCT03998774","phase":"","title":"Evaluation Ofe the Anxiolytic Effect of EMONO in Children During Dental Care (MOPEA)","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2018-03-16","conditions":"Dental Care for Children","enrollment":17},{"nctId":"NCT03453411","phase":"","title":"Effects of EMONO in Children During Dental Care","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2018-05-17","conditions":"Dental Care","enrollment":679},{"nctId":"NCT04095494","phase":"","title":"Study Of the Nitrous Oxide Perception in Health Students","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2019-05-01","conditions":"Nitrous Oxide Abuse","enrollment":250},{"nctId":"NCT02957851","phase":"PHASE2","title":"EMONO for the Treatment of Peripheral Neuropathic Pain","status":"COMPLETED","sponsor":"Air Liquide Santé International","startDate":"2016-11","conditions":"Neuralgia","enrollment":287},{"nctId":"NCT02580565","phase":"","title":"Prevalence of Problematic Use of Equimolar Mixture of Oxygen and Nitrous Oxide and Analgesics in the Sickle-cell Disease","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2015-09-25","conditions":"Sickle Cell Disease","enrollment":1004},{"nctId":"NCT00623220","phase":"PHASE3","title":"Inhaled Nitrous Oxide for Pain Relief During Eye Exam in the Pre-term Infant","status":"COMPLETED","sponsor":"Nabeel Ali","startDate":"2008-03","conditions":"Retinopathy of Prematurity","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":29,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Nitrous Oxide/Oxygen","Nitrous oxide"],"phase":"phase_3","status":"active","brandName":"EMONO","genericName":"EMONO","companyName":"Air Liquide Santé International","companyId":"air-liquide-sant-international","modality":"Small molecule","firstApprovalDate":"","aiSummary":"EMONO is a medical gas mixture (likely nitric oxide-based) designed to improve oxygenation and reduce pulmonary hypertension in critically ill patients. Used for Acute respiratory distress syndrome (ARDS) or severe hypoxemia (Phase 3 indication pending confirmation).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}