{"id":"emollient-moisturizer","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Folliculitis"}]},"_chembl":{"chemblId":"CHEMBL2109152","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Emollients are lipophilic substances that penetrate the stratum corneum and create a hydrophobic film on the skin, preventing water evaporation and improving skin barrier function. They soften and smooth the skin by filling in gaps between desquamated cells and restoring the skin's natural moisture content. This mechanism is particularly useful in treating dry skin conditions and maintaining skin integrity.","oneSentence":"An emollient moisturizer works by forming an occlusive barrier on the skin surface to reduce transepidermal water loss and restore skin hydration.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:10:47.216Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry skin conditions"},{"name":"Xerosis"},{"name":"Skin barrier dysfunction"}]},"trialDetails":[{"nctId":"NCT05590585","phase":"PHASE4","title":"Dupilumab in Adolescent and Adult Skin of Color Participants: Open-label Moderate-to-severe Eczema Trial","status":"COMPLETED","sponsor":"Regeneron Pharmaceuticals","startDate":"2023-01-11","conditions":"Moderate-to-Severe Atopic Dermatitis, Atopic Eczema","enrollment":124},{"nctId":"NCT06565117","phase":"NA","title":"Efficacy of Dipotassium Glycyrrhizinate Emollients in the Maintenance Treatment of Adult Atopic Dermatitis","status":"COMPLETED","sponsor":"The Affiliated Hospital of Xuzhou Medical University","startDate":"2021-10-01","conditions":"Adult Atopic Dermatitis","enrollment":120},{"nctId":"NCT06553417","phase":"NA","title":"Emollient 'Plus' vs Urea 10% for Mild-Moderate Atopic Dermatitis","status":"COMPLETED","sponsor":"Dr. Soetomo General Hospital","startDate":"2023-06-01","conditions":"Dermatitis, Atopic","enrollment":60},{"nctId":"NCT03912259","phase":"PHASE3","title":"Evaluation of Dupilumab in Chinese Adult Patients With Moderate to Severe Atopic Dermatitis","status":"COMPLETED","sponsor":"Sanofi","startDate":"2018-12-19","conditions":"Atopic Dermatitis","enrollment":165},{"nctId":"NCT05961579","phase":"PHASE3","title":"Evaluating the Efficacy and Safety of Cleanser, Serum, and Sunscreen Products for Facial Redness.","status":"UNKNOWN","sponsor":"Goldman, Butterwick, Fitzpatrick and Groff","startDate":"2023-08-11","conditions":"Redness","enrollment":20},{"nctId":"NCT03389308","phase":"PHASE2","title":"Long Term Open-label Study Evaluating Safety of Diacerein 1% Ointment Topical Formulation in Subjects With Epidermolysis Bullosa Simplex","status":"COMPLETED","sponsor":"Castle Creek Pharmaceuticals, LLC","startDate":"2017-12-01","conditions":"Epidermolysis Bullosa, Epidermolysis Bullosa Simplex","enrollment":51},{"nctId":"NCT04045314","phase":"NA","title":"Effect of an Emollient Cream Containing 0.5% Cannabidiol and 1% Hemp Oil in the Hydration and Erythema of the Skin","status":"COMPLETED","sponsor":"Avicanna Inc","startDate":"2019-08-15","conditions":"Cosmetics; Eczema","enrollment":49},{"nctId":"NCT01979016","phase":"PHASE2","title":"Study to Determine the Safety and Effectiveness of Dupilumab for Treatment of Atopic Dermatitis (AD)","status":"COMPLETED","sponsor":"Regeneron Pharmaceuticals","startDate":"2013-12-31","conditions":"Atopic Dermatitis (AD)","enrollment":54},{"nctId":"NCT04065035","phase":"NA","title":"A Clinical Study to Evaluate Efficacy and Tolerability of a Cosmetic Product for Arm Firming","status":"COMPLETED","sponsor":"Revision Skincare","startDate":"2018-12-13","conditions":"Photodamaged Skin, Skin Care","enrollment":46},{"nctId":"NCT01291940","phase":"NA","title":"The Effects of Emollient Therapy on the Skin Barrier","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2011-01","conditions":"Atopic Dermatitis, Eczema","enrollment":25},{"nctId":"NCT03673059","phase":"NA","title":"Clinical Trial to Assess the Effects of Topical Lotions on Changes in the Skin Microbiome and Associations With Itch","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Products Company Division of Johnson & Johnson Consumer Companies, Inc.","startDate":"2015-03-27","conditions":"Microbiota","enrollment":91},{"nctId":"NCT02224950","phase":"NA","title":"Study to Examine the Benefits of Fabric Made With Lyocell/Chitosan/Ceramide in the Treatment of Children With Mild to Moderate Eczema","status":"WITHDRAWN","sponsor":"University of Minnesota","startDate":"2014-11","conditions":"Atopic Dermatitis","enrollment":""},{"nctId":"NCT01577628","phase":"NA","title":"Daily Use of Lipikar Balm AP From Birth in Infants at High Risk of Developing Atopic Dermatitis","status":"TERMINATED","sponsor":"Cosmetique Active International","startDate":"2012-06","conditions":"Atopic Dermatitis, Eczema, Asthma","enrollment":2},{"nctId":"NCT00332163","phase":"PHASE2","title":"Skin Toxicity Treatment in Metastatic Colorectal Cancer (mCRC) Patients Receiving Panitumumab + Irinotecan-based Therapy","status":"COMPLETED","sponsor":"Amgen","startDate":"2006-04","conditions":"Metastatic Colorectal Cancer, Skin Rash, Skin Toxicities","enrollment":95}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":288,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Emollient (moisturizer)","genericName":"Emollient (moisturizer)","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"An emollient moisturizer works by forming an occlusive barrier on the skin surface to reduce transepidermal water loss and restore skin hydration. Used for Dry skin conditions, Xerosis, Skin barrier dysfunction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}