{"id":"emodepside-bay-44-4400","safety":{"commonSideEffects":[{"rate":"null","effect":"Gastrointestinal disturbances"}]},"_chembl":{"chemblId":"CHEMBL2104404","moleculeType":"Small molecule","molecularWeight":"1119.41"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This mechanism of action results in an increase in chloride ion permeability in the nematode muscle and pharyngeal muscle, leading to paralysis and death of the parasite.","oneSentence":"Emodepside is a benzimidazole anthelmintic that acts as a glutamate-gated chloride channel agonist.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:10:43.261Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of cutaneous and visceral larva migrans, strongyloidiasis, and other nematode infections"}]},"trialDetails":[{"nctId":"NCT06736691","phase":"PHASE3","title":"Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections","status":"ENROLLING_BY_INVITATION","sponsor":"Swiss Tropical & Public Health Institute","startDate":"2025-11-25","conditions":"Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection","enrollment":315},{"nctId":"NCT06800248","phase":"PHASE3","title":"Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections","status":"NOT_YET_RECRUITING","sponsor":"Swiss Tropical & Public Health Institute","startDate":"2026-04","conditions":"Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection","enrollment":315},{"nctId":"NCT06412926","phase":"PHASE1","title":"A Study to Learn About How Much Emodepside Gets Absorbed in the Blood and How Food Affects Its Absorption When Given as a New Type of Tablet to Healthy Participants","status":"COMPLETED","sponsor":"Bayer","startDate":"2024-05-07","conditions":"Soil-transmitted Helminth Infection, Onchocerciasis (River Blindness)","enrollment":14},{"nctId":"NCT05180461","phase":"PHASE2","title":"Emodepside Phase II Trial for Treatment of Onchocerciasis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Drugs for Neglected Diseases","startDate":"2021-08-30","conditions":"Onchocerciasis","enrollment":578},{"nctId":"NCT03383614","phase":"PHASE1","title":"Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside","status":"COMPLETED","sponsor":"Drugs for Neglected Diseases","startDate":"2017-11-14","conditions":"Filariasis","enrollment":24},{"nctId":"NCT02661178","phase":"PHASE1","title":"First in Man Clinical Trial of Emodepside (BAY 44-4400)","status":"COMPLETED","sponsor":"Drugs for Neglected Diseases","startDate":"2015-12","conditions":"Healthy Volunteers","enrollment":79},{"nctId":"NCT03383523","phase":"PHASE1","title":"Relative Bioavailability Study of Emodepside IR-tablets and Solution","status":"COMPLETED","sponsor":"Drugs for Neglected Diseases","startDate":"2017-10-26","conditions":"Filariasis","enrollment":77}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Profender® (in combination with praziquantel) FOR VETERINARY USE","Procox® (in combination with toltrazuril) FOR VETERINARY USE"],"phase":"phase_3","status":"active","brandName":"emodepside (BAY 44-4400)","genericName":"emodepside (BAY 44-4400)","companyName":"Swiss Tropical & Public Health Institute","companyId":"swiss-tropical-public-health-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Emodepside (BAY 44-4400) is a small molecule used in clinical trials to study its safety, tolerability, and pharmacokinetics in treating various parasitic infections, including filariasis, soil-transmitted helminth infection, onchocerciasis, trichuris trichiura infection, hookworm infection, and others. It is being investigated in clinical trials as a potential treatment for these conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}