{"id":"emla-topical-product","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin blanching or erythema"},{"rate":null,"effect":"Temporary skin irritation"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"EMLA (Eutectic Mixture of Local Anesthetics) works by penetrating the skin and numbing nerve endings through inhibition of sodium influx in nerve cell membranes. The eutectic formulation allows both lidocaine and prilocaine to exist as an oil-in-water emulsion at room temperature, enhancing skin penetration. This produces reversible local anesthesia suitable for minor surgical procedures and painful dermatological treatments.","oneSentence":"EMLA is a topical anesthetic cream containing lidocaine and prilocaine that blocks sodium channels in nerve fibers to produce local anesthesia and analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:10:47.130Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia for minor surgical procedures and skin procedures"},{"name":"Pain relief for dermatological treatments"}]},"trialDetails":[{"nctId":"NCT06223659","phase":"PHASE2","title":"EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers","status":"RECRUITING","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2023-12-19","conditions":"Cutaneous Melanoma, Merkel Cell Carcinoma, Skin Squamous Cell Carcinoma","enrollment":100},{"nctId":"NCT04523961","phase":"PHASE2, PHASE3","title":"Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2021-01-08","conditions":"Anesthesia, Local, Photodamaged Skin, Topical and Infiltration Anesthetic Toxicity","enrollment":22},{"nctId":"NCT01802086","phase":"NA","title":"Emla-Cream as Pain Relief During Pneumococcal Vaccination","status":"COMPLETED","sponsor":"Beatrice Olsson Duse","startDate":"2013-05","conditions":"Children, Pain","enrollment":72},{"nctId":"NCT06891794","phase":"NA","title":"Use of Cervical Cap and Menstrual Disc for Application of Topical Anesthetic Prior to IUD Insertion","status":"RECRUITING","sponsor":"Oregon Health and Science University","startDate":"2025-08-04","conditions":"IUD","enrollment":24},{"nctId":"NCT05694858","phase":"PHASE1, PHASE2","title":"Transdermal Microneedle Lignocaine Delivery Versus EMLA Patch for Topical Analgesia Before Venepuncture Procedure To Adults in Clinical Setting","status":"RECRUITING","sponsor":"Universiti Kebangsaan Malaysia Medical Centre","startDate":"2025-02-17","conditions":"Glaucoma, Cataract, Ophthalmological Disorder","enrollment":154},{"nctId":"NCT06779448","phase":"NA","title":"The Effect of Rubber Dam on Objective and Subjective Parameters of Stress During Dental Treatment in Children","status":"COMPLETED","sponsor":"Izmir Katip Celebi University","startDate":"2024-07-01","conditions":"Dental Anxiety, Dental Fear, Rubberdam","enrollment":100},{"nctId":"NCT06043063","phase":"NA","title":"Local Anesthesia Before Bulkamid Injection","status":"TERMINATED","sponsor":"Medstar Health Research Institute","startDate":"2023-09-01","conditions":"Stress Urinary Incontinence, Intrinsic Sphincter Deficiency","enrollment":23},{"nctId":"NCT02318654","phase":"PHASE4","title":"Ice Versus EMLA for Pain in Laser Hair Removal","status":"ACTIVE_NOT_RECRUITING","sponsor":"Northwestern University","startDate":"2014-12-30","conditions":"Hair Removal","enrollment":30},{"nctId":"NCT06777199","phase":"NA","title":"A Comparative Study of Selective Dorsal Neurectomy, Pulsed Radiofrequency Neuromodulation, and Intragranular Hyaluronic Acid Injection for Premature Ejaculation","status":"COMPLETED","sponsor":"Ahmed Hamdy Ahmed","startDate":"2022-07-01","conditions":"Premature Ejaculation","enrollment":30},{"nctId":"NCT06767085","phase":"PHASE4","title":"Pain Management During Diagnostic Office Hysteroscopy in Postmenopausal Women: a Randomized Study","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-02-05","conditions":"Office Hysteroscopy","enrollment":106},{"nctId":"NCT05891132","phase":"NA","title":"Comparison Between Lidocaine Prilocaine Cream and Lidocaine Injection on Pain Control During Episiotomy.","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-09-01","conditions":"Episiotomy Wound","enrollment":60},{"nctId":"NCT06242977","phase":"PHASE3","title":"Efficacy of EMLA Cream Assisted Loco-sedation for Office-based Andrology Procedures","status":"UNKNOWN","sponsor":"University of Manitoba","startDate":"2024-01-25","conditions":"Scrotum Disease, Hydrocele Male, Spermatocele","enrollment":72},{"nctId":"NCT05497323","phase":"PHASE1","title":"Effectivity and Safety of Combination Cream of Salicylic Acid, Aqua Posae Filiformis, Niacinamide, Lipohydroxy Acid, Procerad and Zinc PCA","status":"UNKNOWN","sponsor":"Dr.dr.Irma Bernadette, SpKK (K)","startDate":"2022-08-01","conditions":"Acne Vulgaris","enrollment":284},{"nctId":"NCT04337814","phase":"NA","title":"The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electrodiagnostic Testing","status":"COMPLETED","sponsor":"Aga Khan University Hospital, Pakistan","startDate":"2019-12-30","conditions":"Pain Perception","enrollment":113},{"nctId":"NCT03813030","phase":"NA","title":"An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques","status":"COMPLETED","sponsor":"Joanneum Research Forschungsgesellschaft mbH","startDate":"2019-01-16","conditions":"Healthy, Dermal Pharmacokinetic Measurement","enrollment":26},{"nctId":"NCT04858360","phase":"NA","title":"Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens","status":"COMPLETED","sponsor":"Aalborg University","startDate":"2021-11-15","conditions":"Itch","enrollment":22},{"nctId":"NCT05580029","phase":"EARLY_PHASE1","title":"Fractional CO2 Laser Fenestration and Steroid Delivery in HS Lesions","status":"UNKNOWN","sponsor":"University of Southern California","startDate":"2022-11-01","conditions":"Scar, Hidradenitis Suppurativa","enrollment":10},{"nctId":"NCT05078463","phase":"PHASE2","title":"Efficacy of Transdermal Microneedle Patch for Topical Anesthesia Enhancement in Paediatric Thalassemia Patients","status":"COMPLETED","sponsor":"Universiti Kebangsaan Malaysia Medical Centre","startDate":"2021-09-15","conditions":"Thalassemia in Children","enrollment":20},{"nctId":"NCT04959409","phase":"","title":"Topical Analgesia Before Inhalational Anaesthesia","status":"COMPLETED","sponsor":"Nottingham University Hospitals NHS Trust","startDate":"2020-08-01","conditions":"Anesthesia, Pediatric ALL","enrollment":500},{"nctId":"NCT04076865","phase":"NA","title":"Evaluation of the Effect Induced by Repeated Administration of Topical Local Anaesthetic (EMLA) on Itch","status":"COMPLETED","sponsor":"Aalborg University","startDate":"2019-10-15","conditions":"Lidocaine, Itch","enrollment":26},{"nctId":"NCT04050826","phase":"NA","title":"An Exploratory Study in Healthy Volunteers to Identify Factors Influencing Bioequivalence Studies on Moderately Lipophilic Drugs Using Dermal Open Flow Microperfusion (dOFM)","status":"COMPLETED","sponsor":"Joanneum Research Forschungsgesellschaft mbH","startDate":"2019-09-01","conditions":"Healthy, Dermal Pharmacokinetic Measurements","enrollment":20},{"nctId":"NCT04467125","phase":"PHASE4","title":"Nexplanon Removal: Subcutaneous vs. Topical Lidocaine","status":"UNKNOWN","sponsor":"Augusta University","startDate":"2020-01-06","conditions":"Contraception","enrollment":40},{"nctId":"NCT04378283","phase":"NA","title":"Prospective Evaluation of Topical Anesthesia in Children","status":"COMPLETED","sponsor":"Universitätsklinikum Hamburg-Eppendorf","startDate":"2016-05","conditions":"Skin Lacerations","enrollment":99},{"nctId":"NCT03654417","phase":"PHASE4","title":"Pain Perception During Vulvar Biopsy","status":"TERMINATED","sponsor":"Duke University","startDate":"2018-09-17","conditions":"Any Condition Requiring Vulvar Biopsy","enrollment":37},{"nctId":"NCT01516684","phase":"PHASE2","title":"Local Anesthetic Cream in Younger Patients Undergoing Lumbar Punctures","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2012-05-14","conditions":"Malignant Neoplasm","enrollment":33},{"nctId":"NCT01628874","phase":"NA","title":"Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children","status":"TERMINATED","sponsor":"University of Colorado, Denver","startDate":"2012-09","conditions":"Lumbar Puncture, Topical Analgesia","enrollment":66},{"nctId":"NCT03484832","phase":"PHASE4","title":"Spray vs EMLA Cream on Pain During Intra-articular Injection","status":"UNKNOWN","sponsor":"Soonchunhyang University Hospital","startDate":"2018-03-14","conditions":"Adhesive Capsulitis of the Shoulder","enrollment":63},{"nctId":"NCT02548533","phase":"PHASE4","title":"Fractional Laser Assisted Topical Anesthesia","status":"TERMINATED","sponsor":"Netherlands Institute for Pigment Disorders","startDate":"2015-06","conditions":"Cicatrix","enrollment":3},{"nctId":"NCT03459833","phase":"PHASE3","title":"Glans Penis Augmentation by Hyaluronic Acid for Treatment of Premature Ejaculation","status":"COMPLETED","sponsor":"Cairo University","startDate":"2016-08-19","conditions":"Premature Ejaculation","enrollment":30},{"nctId":"NCT03187392","phase":"PHASE3","title":"Pain Relief for Birth Control Implants Insertion","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2017-06-12","conditions":"Contraception, Lidocaine","enrollment":144},{"nctId":"NCT03441841","phase":"PHASE1","title":"Pharmacokinetic Study of Nanoencapsulated Gel of Lidocaine, Prilocaine and Combination of Lidocaine and Prilocaine","status":"COMPLETED","sponsor":"Galeno Desenvolvimento de Pesquisas Clínicas","startDate":"2016-02-28","conditions":"Topical Anesthesia","enrollment":48},{"nctId":"NCT03366246","phase":"PHASE3","title":"Efficacy of a Topical Anesthetic Containing Lidocaine and Prilocaine in Treatment With CO2 Fractional Laser","status":"COMPLETED","sponsor":"Galeno Desenvolvimento de Pesquisas Clínicas","startDate":"2014-06-07","conditions":"Lidocaine Adverse Reaction, Prilocaine Adverse Reaction","enrollment":120},{"nctId":"NCT02990364","phase":"PHASE3","title":"Combination Analgesia for Neonatal Circumcision","status":"COMPLETED","sponsor":"American University of Beirut Medical Center","startDate":"2015-12","conditions":"Analgesia","enrollment":70},{"nctId":"NCT02380742","phase":"PHASE2","title":"Topical Anesthetic Use In Pessary Management","status":"COMPLETED","sponsor":"Loyola University","startDate":"2015-07","conditions":"Pain","enrollment":54},{"nctId":"NCT02976727","phase":"PHASE1","title":"Efficacy of Topical Calcipotriol-assisted AFL-PDT in Actinic Keratosis","status":"COMPLETED","sponsor":"Dong-A University","startDate":"2014-05","conditions":"Actinic Dermatosis","enrollment":48},{"nctId":"NCT00556478","phase":"PHASE2, PHASE3","title":"Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation","status":"COMPLETED","sponsor":"Plethora Solutions Ltd","startDate":"2007-10","conditions":"Premature Ejaculation","enrollment":256},{"nctId":"NCT02839928","phase":"NA","title":"Nasal Ketamine for Minor Procedures in Children","status":"UNKNOWN","sponsor":"Kaplan Medical Center","startDate":"2016-07","conditions":"Pain","enrollment":20},{"nctId":"NCT02549105","phase":"PHASE4","title":"Lidocaine-Prilocaine Cream (EMLA) Topical Application Versus Wound Infiltration With Lidocaine After Cesarean Section","status":"UNKNOWN","sponsor":"Ain Shams Maternity Hospital","startDate":"2014-10","conditions":"Post Operative Pain","enrollment":80},{"nctId":"NCT00444626","phase":"PHASE3","title":"A Study to Compare the Safety and Effectiveness of a Non-FDA Approved Device Dermal Gel Extra (DGE) and an FDA Approved Device for the Correction of Nasolabial Folds (NLFs)","status":"COMPLETED","sponsor":"Genzyme, a Sanofi Company","startDate":"2007-05","conditions":"Facial Wrinkles at the Nasolabial Folds","enrollment":140},{"nctId":"NCT02246179","phase":"PHASE4","title":"Fractional Laser Assisted Delivery of Anesthetics","status":"COMPLETED","sponsor":"Netherlands Institute for Pigment Disorders","startDate":"2014-09","conditions":"Local Anesthesia of the Skin.","enrollment":10},{"nctId":"NCT01963559","phase":"NA","title":"Cutaneous Microcirculation and Diabetic Foot","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2012-04","conditions":"Diabetic Foot Proned Patients","enrollment":80},{"nctId":"NCT01860235","phase":"NA","title":"EMLA Topical Anesthetic During Scaling and Root Planing","status":"COMPLETED","sponsor":"Franciscan University Center","startDate":"2010-06","conditions":"Local Anesthesia, Pain, Postoperative, Self-Perception","enrollment":32},{"nctId":"NCT01606046","phase":"PHASE4","title":"Comparison of the Effects of Vapocoolant Spray and EMLA Cream on Pain During Needle Electromyography","status":"COMPLETED","sponsor":"The Catholic University of Korea","startDate":"2011-07","conditions":"Electrodiagnosis","enrollment":99},{"nctId":"NCT01540877","phase":"NA","title":"A Human Experimental Model for Neuropathic Pain Using Combined Application of Capsaicin and Local Anesthetics","status":"COMPLETED","sponsor":"Ruhr University of Bochum","startDate":"2011-04","conditions":"Ipsi- and Contralateral Hypoesthesia","enrollment":28}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Eutectic Mixture of Local Anesthetics"],"phase":"phase_3","status":"active","brandName":"EMLA Topical Product","genericName":"EMLA Topical Product","companyName":"American University of Beirut Medical Center","companyId":"american-university-of-beirut-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"EMLA is a topical anesthetic cream containing lidocaine and prilocaine that blocks sodium channels in nerve fibers to produce local anesthesia and analgesia. Used for Topical anesthesia for minor surgical procedures and skin procedures, Pain relief for dermatological treatments.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}