{"id":"em-100","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"EM-100 targets the Wnt signaling cascade, which plays a key role in pathological corneal neovascularization and inflammatory responses in the eye. By inhibiting this pathway, the drug aims to suppress abnormal blood vessel growth and reduce corneal opacity and inflammation associated with various corneal conditions.","oneSentence":"EM-100 is a small molecule that inhibits the Wnt/β-catenin signaling pathway to reduce corneal neovascularization and inflammation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:44:21.804Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Corneal neovascularization"},{"name":"Corneal scarring and opacity"}]},"trialDetails":[{"nctId":"NCT03489941","phase":"PHASE3","title":"A Single-Center Evaluation of the Relative Efficacy of EM-100 Compared to Zaditor® (Ketotifen Fumarate Ophthalmic Solution 0.035%) and Vehicle","status":"COMPLETED","sponsor":"Bausch & Lomb Incorporated","startDate":"2018-04-07","conditions":"Allergic Conjunctivitis","enrollment":65}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":25,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"EM-100","genericName":"EM-100","companyName":"Bausch & Lomb Incorporated","companyId":"bausch-lomb-incorporated","modality":"Small molecule","firstApprovalDate":"","aiSummary":"EM-100 is a small molecule that inhibits the Wnt/β-catenin signaling pathway to reduce corneal neovascularization and inflammation. Used for Corneal neovascularization, Corneal scarring and opacity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}