{"id":"elrantamab","rwe":[],"tags":[],"safety":{"boxedWarnings":[],"drugInteractions":[{"drug":"Bleeding risk may be increased with anticoagulants","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Bleeding risk may be increased with antiplatelet agents","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Bleeding risk may be increased with fibrinolytics","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Bleeding risk may be increased with heparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Bleeding risk may be increased with low molecular weight heparin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Bleeding risk may be increased with thrombin inhibitors","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Bleeding risk may be increased with warfarin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Avoid use of live 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Human immunoglobulin (IgG) is known to cross the placenta after the first trimester of pregnancy. Based on  the mechanism of action, elranatamab may cause foetal harm when administered to a pregnant woman and therefore ELREXFIO is not recommended for use during pregnancy. ELREXFIO is associated with hypogammaglobulinaemia, therefore, assessment of immunoglobulin   ...    It is not known whether elranatamab is excreted in human or animal milk, affects breastfed infants or not.","Geriatric use":"Elderly  No dose adjustment is necessary (see sections 5.1 and 5.2).","Paediatric use":"There is no relevant use of ELREXFIO in the paediatric population for the treatment of multiple myeloma. ELREXFIO is not intended for children or adolescents below 18 years of age. This is because it is not   ...    (e.g., cyclosporine, phenytoin, sirolimu","Renal impairment":"No dose adjustment is recommended in patients with mild to moderate renal impairment (estimated   ...    severe renal impairment, see section 5.2).","Hepatic impairment":"No dose adjustments are required for mild hepatic impairment (total bilirubin > 1 to 1.5 × ULN and any AST, or total bilirubin ≤ ULN and AST > ULN, see section 5.2)."}},"trials":[],"_chembl":null,"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=elrantamab","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:56:18.686100+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-19T23:56:37.106305+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:56:24.297779+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:56:18.753305+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=elrantamab","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:56:24.667900+00:00"}},"offLabel":[],"timeline":[{"date":"2021-06-01","type":"Clinical","milestone":"Phase 1/2 Trial Initiation","regulator":"FDA"},{"date":"2022-12-01","type":"Clinical","milestone":"Phase 2 Data Presentation","regulator":"ASCO"},{"date":"2023-09-01","type":"Clinical","milestone":"Phase 3 Trial Initiation","regulator":"FDA"}],"_dailymed":null,"aiSummary":"Elrantamab, marketed by Pfizer, is a bispecific antibody targeting relapsed or refractory multiple myeloma, positioning it in a competitive landscape alongside Blinatumomab, Teclistamab, and Mosunetuzumab. Its key strength lies in its mechanism of action, which facilitates T-cell-mediated cytotoxicity against tumor cells, potentially offering enhanced efficacy. The primary risk is the key composition patent expiry in 2028, which could lead to increased competition from generics and biosimilars.","brandName":"Elrantamab","ecosystem":[],"isGeneric":true,"mechanism":{"target":"BCMA (B-cell maturation antigen)","novelty":"Elrantamab represents a novel approach in the treatment of multiple myeloma by leveraging bispecific antibodies to enhance T-cell engagement and tumor cell killing.","modality":"Immunotherapy","drugClass":"Bispecific Antibody","explanation":"","oneSentence":"","technicalDetail":"The bispecific nature of elrantamab allows for the formation of a ternary complex between the T cell, the antibody, and the tumor cell, enhancing the specificity and potency of the immune response against multiple myeloma."},"_companyIR":{"url":"https://www.pfizer.com/investors","revenueRefs":[],"pipelineRefs":[]},"_scrapedAt":"2026-03-27T23:28:38.660Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"commercial":{"yoyGrowth":"","launchDate":null,"annualCostUS":"$80,000/yr","genericStatus":"Generic — off-patent","currentRevenue":"$21.2B","patientPopulation":"Patients with relapsed or refractory multiple myeloma","peakSalesEstimate":"$21.2B"},"references":[{"id":1,"url":"https://clinicaltrials.gov/search?intr=elrantamab","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=elrantamab","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.ema.europa.eu/","fields":["regulatoryStatus"],"source":"European Medicines Agency (EMA)"},{"id":4,"url":"https://list.essentialmeds.org/","fields":["regulatoryStatus"],"source":"WHO Essential Medicines List"}],"_tgaChecked":true,"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-19T23:56:37.106387+00:00","fieldsConflicting":2,"overallConfidence":0.8},"_whoChecked":true,"biosimilars":[],"competitors":["Blinatumomab (Amgen)","Teclistamab (Janssen Biotech)","Mosunetuzumab (Genentech)"],"genericName":"elrantamab","indications":{"approved":[{"name":"Relapsed or refractory multiple myeloma","regulator":"FDA"}],"offLabel":[],"pipeline":["Relapsed or Refractory Multiple Myeloma"]},"_mhraChecked":true,"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06483100","phase":"PHASE2","title":"Measurable Residual Disease-Guided Post-Transplant Elranatamab Maintenance","status":"RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2024-12-20","conditions":"Multiple Myeloma","enrollment":65}],"_emaApprovals":[{"date":"","name":"Elrantamab","status":"Authorised","regulator":"EMA"}],"_faersSignals":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"_patentsChecked":true,"_warningLetters":[{"date":"03/28/2023","subject":"11/07/2022\tTodos Medical Ltd aka Todos Medical USA Inc\tCenter for Food Safety and Applied Nutrition"},{"date":"03/27/2026","subject":"Feedback form"}],"formularyStatus":[],"_approvalHistory":[],"_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[],"_drugWebsiteChecked":true,"_healthCanadaChecked":true,"companionDiagnostics":[],"_genericFilersChecked":true,"genericManufacturerList":[],"phase":"marketed","status":"active","companyName":"Pfizer","companyId":"pfizer","modality":"Monoclonal antibody","firstApprovalDate":"","enrichmentLevel":3,"visitCount":3,"regulatoryByCountry":[{"country_code":"EU","regulator":"EMA","status":"pending","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"pricingByCountry":[{"country_code":"US","currency":"USD","price_amount":"80000.00","price_per":"year","price_type":"annual_list","annual_cost_usd":null,"reimbursement_status":null}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-19T23:56:37.106387+00:00","fieldsConflicting":2,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}