{"id":"elimite-cream-permethrin-5","safety":{"commonSideEffects":[{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Burning sensation"},{"rate":null,"effect":"Tingling or numbness"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Permethrin acts as a neurotoxin by binding to voltage-gated sodium channels in arthropod nerve and muscle cells, preventing normal repolarization and leading to sustained depolarization. This results in paralysis and death of the parasite. The drug is selectively toxic to arthropods due to their greater sensitivity compared to mammals, which have different sodium channel kinetics and metabolism.","oneSentence":"Permethrin is a synthetic pyrethroid insecticide that disrupts sodium channel function in the nervous system of parasites, causing paralysis and death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:10:50.107Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Scabies (Sarcoptes scabiei infestation)"},{"name":"Head lice (Pediculus humanus capitis infestation)"}]},"trialDetails":[{"nctId":"NCT03973775","phase":"PHASE3","title":"A Bioequivalence Study With Clinical Endpoints to Evaluate the Safety and Therapeutic Equivalence of Permethrin Cream 5% & Elimite™ in Subjects With Scabies","status":"COMPLETED","sponsor":"Saptalis Pharmaceuticals LLC","startDate":"2018-04-10","conditions":"Scabies","enrollment":126},{"nctId":"NCT02978508","phase":"PHASE3","title":"Bio-equivalence Study Comparing Permethrin Cream, 5% With Elimite in Patients With Active Scabies.","status":"COMPLETED","sponsor":"Mayne Pharma International Pty Ltd","startDate":"2016-11","conditions":"Scabies","enrollment":140},{"nctId":"NCT03178942","phase":"PHASE3","title":"Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies","status":"COMPLETED","sponsor":"Encube Ethicals Pvt. Ltd.","startDate":"2017-06-01","conditions":"Scabies","enrollment":254},{"nctId":"NCT02572986","phase":"PHASE3","title":"A Study to Evaluate the Therapeutic Equivalence of Generic Permethrin Cream 5% to Elimite® in the Treatment of Scabies","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2015-09","conditions":"Scabies","enrollment":250}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":64,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Elimite™ Cream"],"phase":"phase_3","status":"active","brandName":"Elimite™ Cream (permethrin) 5%","genericName":"Elimite™ Cream (permethrin) 5%","companyName":"Encube Ethicals Pvt. Ltd.","companyId":"encube-ethicals-pvt-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Permethrin is a synthetic pyrethroid insecticide that disrupts sodium channel function in the nervous system of parasites, causing paralysis and death. Used for Scabies (Sarcoptes scabiei infestation), Head lice (Pediculus humanus capitis infestation).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}