{"id":"elidel-creme","safety":{"commonSideEffects":[{"rate":"10-25","effect":"Application site burning or irritation"},{"rate":"1-5","effect":"Headache"},{"rate":"1-5","effect":"Nasopharyngitis"},{"rate":"1-5","effect":"Skin infections"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pimecrolimus binds to macrophilin-12 and inhibits calcineurin, preventing dephosphorylation and nuclear translocation of NFAT, which blocks T-cell proliferation and release of inflammatory mediators. This localized immunosuppression reduces the inflammatory cascade characteristic of atopic dermatitis without the systemic effects of topical corticosteroids.","oneSentence":"Elidel (pimecrolimus) is a calcineurin inhibitor that suppresses T-cell activation and inflammatory cytokine production in the skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:29:06.643Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atopic dermatitis (eczema) in adults and children ≥2 years"},{"name":"Short-term and intermittent long-term treatment of mild to moderate atopic dermatitis"}]},"trialDetails":[{"nctId":"NCT00180141","phase":"PHASE4","title":"Elidel-Study: Elidel in Patients With Atopic Dermatitis","status":"COMPLETED","sponsor":"Technische Universität Dresden","startDate":"2005-04","conditions":"Atopic Dermatitis","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Elidel-Creme","genericName":"Elidel-Creme","companyName":"Technische Universität Dresden","companyId":"technische-universit-t-dresden","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Elidel (pimecrolimus) is a calcineurin inhibitor that suppresses T-cell activation and inflammatory cytokine production in the skin. Used for Atopic dermatitis (eczema) in adults and children ≥2 years, Short-term and intermittent long-term treatment of mild to moderate atopic dermatitis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}