{"id":"eledoisin","rwe":[{"pmid":"34924549","year":"2022","title":"Short-term Efficacy and Safety of Biological Tear Substitutes and Topical Secretagogues for Dry Eye Disease: A Systematic Review and Network Meta-analysis.","finding":"","journal":"Cornea","studyType":"Clinical Study"},{"pmid":"23906760","year":"2013","title":"Iatrogenic dry eye disease: an eledoisin/carnitine and osmolyte drops study.","finding":"","journal":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","studyType":"Clinical Study"},{"pmid":"21472584","year":"2011","title":"Structural heterogeneity of doubly-charged peptide b-ions.","finding":"","journal":"Journal of the American Society for Mass Spectrometry","studyType":"Clinical Study"},{"pmid":"16707771","year":"2006","title":"Regulation of the stimulant actions of neurokinin a and human hemokinin-1 on the human uterus: a comparison with histamine.","finding":"","journal":"Biology of reproduction","studyType":"Clinical Study"},{"pmid":"16127708","year":"2005","title":"Species differences in tachykinin receptor distribution: further evidence that the substance P (NK1) receptor predominates in human brain.","finding":"","journal":"The Journal of comparative neurology","studyType":"Clinical Study"}],"tags":[{"label":"Peptide","category":"modality"},{"label":"Neuromedin-K receptor","category":"target"},{"label":"TACR3","category":"gene"},{"label":"TACR1","category":"gene"},{"label":"Active","category":"status"},{"label":"Sjögren's syndrome","category":"indication"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"eledone peptide","offLabel":[],"synonyms":["eledoisin","eledone peptide","ELD 950","ELD-950","eledoisin trifluoroacetate"],"timeline":[],"approvals":[],"brandName":"Eledone Peptide","ecosystem":[{"indication":"Sjögren's syndrome","otherDrugs":[{"name":"prednisolone","slug":"prednisolone","company":""}],"globalPrevalence":50800000}],"mechanism":{"target":"Neuromedin-K receptor","targets":[{"gene":"TACR3","source":"DrugCentral","target":"Neuromedin-K receptor","protein":"Neuromedin-K receptor"},{"gene":"TACR1","source":"DrugCentral","target":"Substance-P receptor","protein":"Substance-P receptor"}],"modality":"Small Molecule","explanation":"Imagine your body has a lock and key system. Eledoisin is a key that fits into a specific lock, called the Neuromedin-K receptor. When the key fits into the lock, it sends a signal to the body, which can help to reduce inflammation and other symptoms associated with Sjögren's syndrome.","oneSentence":"Eledoisin works by binding to the Neuromedin-K receptor, which is involved in various physiological processes.","technicalDetail":"Eledoisin acts as a selective agonist of the Neuromedin-K receptor, activating downstream signaling pathways that modulate immune responses and potentially providing therapeutic benefits for patients with Sjögren's syndrome."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2955","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ELEDOISIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:54:00.437346","biosimilars":[],"competitors":[{"drugName":"aprepitant","drugSlug":"aprepitant","fdaApproval":"2003-03-27","patentExpiry":"Sep 26, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"cefapirin","drugSlug":"cefapirin","fdaApproval":"1974-03-12","relationship":"same-target"},{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"econazole","drugSlug":"econazole","fdaApproval":"1982-12-23","patentExpiry":"Aug 8, 2031","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"fosaprepitant","drugSlug":"fosaprepitant","fdaApproval":"2003-03-27","patentExpiry":"Jan 11, 2039","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"fosnetupitant","drugSlug":"fosnetupitant","fdaApproval":"2018-04-19","relationship":"same-target"},{"drugName":"miconazole","drugSlug":"miconazole","fdaApproval":"1974-01-08","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"netupitant","drugSlug":"netupitant","fdaApproval":"2014-10-10","relationship":"same-target"},{"drugName":"paroxetine","drugSlug":"paroxetine","fdaApproval":"1992-12-29","patentExpiry":"Aug 4, 2026","patentStatus":"Patent protected","relationship":"same-target"}],"genericName":"eledoisin","indications":{"approved":[{"name":"Sjögren's syndrome","source":"DrugCentral","snomedId":83901003,"regulator":"FDA","globalPrevalence":50800000,"prevalenceMethod":"ai-extracted","prevalenceSource":"Ann Rheum Dis, 2015 (PMID:24938285)"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"aprepitant","brandName":"aprepitant","genericName":"aprepitant","approvalYear":"2003","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"},{"drugId":"cefapirin","brandName":"cefapirin","genericName":"cefapirin","approvalYear":"1974","relationship":"same-target"},{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-target"},{"drugId":"econazole","brandName":"econazole","genericName":"econazole","approvalYear":"1982","relationship":"same-target"},{"drugId":"fosaprepitant","brandName":"fosaprepitant","genericName":"fosaprepitant","approvalYear":"2003","relationship":"same-target"},{"drugId":"fosnetupitant","brandName":"fosnetupitant","genericName":"fosnetupitant","approvalYear":"2018","relationship":"same-target"},{"drugId":"miconazole","brandName":"miconazole","genericName":"miconazole","approvalYear":"1974","relationship":"same-target"},{"drugId":"netupitant","brandName":"netupitant","genericName":"netupitant","approvalYear":"2014","relationship":"same-target"},{"drugId":"paroxetine","brandName":"paroxetine","genericName":"paroxetine","approvalYear":"1992","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"OKY3285J18","CHEBI":"CHEBI:135903","INN_ID":"3278","UMLSCUI":"C0013877","ChEMBL_ID":"CHEMBL373569","KEGG_DRUG":"D07936","PUBCHEM_CID":"10328936","IUPHAR_LIGAND_ID":"2086","SECONDARY_CAS_RN":"10129-92-7","MESH_DESCRIPTOR_UI":"D004600"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":564,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2022 Sep 1","pmid":"34924549","title":"Short-term Efficacy and Safety of Biological Tear Substitutes and Topical Secretagogues for Dry Eye Disease: A Systematic Review and Network Meta-analysis.","journal":"Cornea"},{"date":"2013 Sep","pmid":"23906760","title":"Iatrogenic dry eye disease: an eledoisin/carnitine and osmolyte drops study.","journal":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"date":"2011 Feb","pmid":"21472584","title":"Structural heterogeneity of doubly-charged peptide b-ions.","journal":"Journal of the American Society for Mass Spectrometry"},{"date":"2006 Sep","pmid":"16707771","title":"Regulation of the stimulant actions of neurokinin a and human hemokinin-1 on the human uterus: a comparison with histamine.","journal":"Biology of reproduction"},{"date":"2005 Oct 3","pmid":"16127708","title":"Species differences in tachykinin receptor distribution: further evidence that the substance P (NK1) receptor predominates in human brain.","journal":"The Journal of comparative neurology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Recombinant protein","firstApprovalDate":"","aiSummary":"Eledone peptide, also known as Eledoisin, is a protein-based compound. It has several synonyms, including ELD 950, ELD-950, Eledoisin, Eledoisina, and Eledoisine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}