{"id":"electromotive-mitomycin","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Myelosuppression"},{"rate":"5-15%","effect":"Gastrointestinal toxicity"},{"rate":"5-10%","effect":"Skin reactions"}]},"_chembl":{"chemblId":"CHEMBL328333","moleculeType":"Small molecule","molecularWeight":"413.81"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This localized delivery allows for higher concentrations of mitomycin to be achieved at the tumor site, while minimizing systemic exposure and potential side effects. The electromotive force drives the release of mitomycin, which then intercalates DNA strands, inhibiting DNA replication and ultimately leading to cell death.","oneSentence":"Electromotive mitomycin works by releasing mitomycin, an alkylating agent, directly into the tumor site.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:10:39.696Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Locally advanced or metastatic solid tumors"}]},"trialDetails":[{"nctId":"NCT04311580","phase":"PHASE2","title":"Intravesical Electromotive Mitomycin After Bacillus Calmette-Guérin Failure","status":"COMPLETED","sponsor":"University of Rome Tor Vergata","startDate":"2000-01-01","conditions":"Bladder Cancer","enrollment":52},{"nctId":"NCT03664869","phase":"PHASE3","title":"Electromotive Mitomycin-C (EMDA-MMC) in Preventing Recurrences in High-risk Non-muscle-invasive Bladder Cancer","status":"UNKNOWN","sponsor":"Turku University Hospital","startDate":"2018-10-26","conditions":"Bladder Cancer","enrollment":300},{"nctId":"NCT02202044","phase":"NA","title":"Sequential Intravesical Bacillus Calmette-Guérin and Electromotive Mitomycin-C After Transuretheral Resection","status":"TERMINATED","sponsor":"University of Colorado, Denver","startDate":"2015-02-24","conditions":"Bladder Carcinoma","enrollment":13},{"nctId":"NCT01920269","phase":"PHASE2, PHASE3","title":"Intravesical Adjuvant Electromotive Mitomycin-C","status":"COMPLETED","sponsor":"University of Rome Tor Vergata","startDate":"1994-01","conditions":"Bladder Cancer TNM Staging Primary Tumor (T) Ta, Bladder Cancer TNM Staging Primary Tumor (T) T1, Bladder Cancer Transitional Cell Grade","enrollment":331},{"nctId":"NCT01149174","phase":"PHASE3","title":"Preoperative Intravesical Electromotive Mitomycin-c for Primary Non-muscle Invasive Bladder Cancer","status":"COMPLETED","sponsor":"University of Rome Tor Vergata","startDate":"1994-01","conditions":"Superficial Bladder Cancer","enrollment":352},{"nctId":"NCT01442519","phase":"PHASE3","title":"Sequential Bacillus Calmette-Guérin (BCG) and Electromotive Mitomycin-C Versus Bacillus Calmette-Guérin (BCG) Alone for High Risk Superficial Bladder Cancer","status":"COMPLETED","sponsor":"University of Rome Tor Vergata","startDate":"1994-01","conditions":"Bladder Cancer","enrollment":212}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["IMMUCYST, Alpha Wassermann, Bologna, Italy","MITOMYCIN C 40 mg, Kyowa Italiana Farmaceutici"],"phase":"phase_3","status":"active","brandName":"electromotive mitomycin","genericName":"electromotive mitomycin","companyName":"University of Rome Tor Vergata","companyId":"university-of-rome-tor-vergata","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Electromotive mitomycin works by releasing mitomycin, an alkylating agent, directly into the tumor site. Used for Locally advanced or metastatic solid tumors.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}