{"id":"eldecalcitol-capsules","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Hyperphosphatemia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Eldecalcitol is a synthetic analog of 1,25-dihydroxyvitamin D3 that activates the vitamin D receptor (VDR) in target tissues including bone, intestine, and kidney. By binding to VDR, it enhances intestinal calcium and phosphate absorption, suppresses parathyroid hormone secretion, and promotes osteoblast differentiation and bone formation. This mechanism makes it effective in treating osteoporosis and other metabolic bone diseases.","oneSentence":"Eldecalcitol is an active vitamin D analog that binds to the vitamin D receptor to regulate calcium and phosphate metabolism and promote bone mineralization.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:29:03.629Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoporosis"},{"name":"Metabolic bone disease"}]},"trialDetails":[{"nctId":"NCT07063797","phase":"NA","title":"Study on the Intervention Effect of Denosumab on High-Risk Patients With Osteoporotic Fractures in Type 2 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2026-02-01","conditions":"Type 2 Diabetes, Osteoporosis, Fractures","enrollment":358},{"nctId":"NCT06537115","phase":"PHASE4","title":"Clinical Intervention of Idecalcitol Combined With Whey Protein Powder and Exercise for Sarcopenia","status":"RECRUITING","sponsor":"Zhejiang Provincial People's Hospital","startDate":"2024-06-16","conditions":"Sarcopenia","enrollment":450},{"nctId":"NCT05902078","phase":"PHASE4","title":"Eldecalcitol and Calcitriol in Postmenopausal Women With Low Bone Mineral Density or Mild Osteoporosis","status":"RECRUITING","sponsor":"Shanghai Jiao Tong University Affiliated Sixth People's Hospital","startDate":"2023-09-27","conditions":"Low Bone Mineral Density, Postmenopausal Osteoporosis","enrollment":300},{"nctId":"NCT06385093","phase":"PHASE4","title":"A Study on the Prevention and Treatment of GIOP With Eldecalcitol","status":"NOT_YET_RECRUITING","sponsor":"Chinese SLE Treatment And Research Group","startDate":"2024-06","conditions":"Rheumatoid Arthritis, Osteoporosis, Osteopenia","enrollment":314},{"nctId":"NCT05433207","phase":"","title":"Post-Marketing Drug Intensive Monitoring Surveillance of EDIROL in Patients With Postmenopausal Osteoporosis","status":"UNKNOWN","sponsor":"Chugai Pharmaceutical","startDate":"2022-08-01","conditions":"Postmenopausal Osteoporosis","enrollment":1000},{"nctId":"NCT05406050","phase":"PHASE1","title":"Bioequivalence Study of Eldecalcitol Soft Capsule in Healthy Chinese Subjects","status":"COMPLETED","sponsor":"The Affiliated Hospital of Qingdao University","startDate":"2020-10-20","conditions":"Healthy","enrollment":58}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"HERPES ZOSTER"},{"count":2,"reaction":"IMMUNOSUPPRESSION"},{"count":1,"reaction":"ADRENOCORTICOTROPIC HORMONE DEFICIENCY"},{"count":1,"reaction":"ANORECTAL DISORDER"},{"count":1,"reaction":"BLADDER DISORDER"},{"count":1,"reaction":"BLOOD PRESSURE INCREASED"},{"count":1,"reaction":"DECREASED APPETITE"},{"count":1,"reaction":"DIABETIC KETOACIDOSIS"},{"count":1,"reaction":"DYSCHEZIA"},{"count":1,"reaction":"DYSPNOEA"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Edirol"],"phase":"marketed","status":"active","brandName":"Eldecalcitol capsules","genericName":"Eldecalcitol capsules","companyName":"Shanghai Jiao Tong University Affiliated Sixth People's Hospital","companyId":"shanghai-jiao-tong-university-affiliated-sixth-people-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Eldecalcitol is an active vitamin D analog that binds to the vitamin D receptor to regulate calcium and phosphate metabolism and promote bone mineralization. Used for Osteoporosis, Metabolic bone disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}