{"id":"egcg-as-putative-neuroprotective-agent","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Hepatotoxicity (at high doses)"}]},"_chembl":{"chemblId":"CHEMBL4802227","moleculeType":"Small molecule","molecularWeight":"274.11"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"EGCG is a catechin polyphenol that crosses the blood-brain barrier and scavenges reactive oxygen species while inhibiting pro-inflammatory signaling cascades implicated in neurodegeneration. It may also modulate protein misfolding and aggregation pathways relevant to neurodegenerative diseases, potentially stabilizing neuronal function and reducing cell death.","oneSentence":"EGCG (epigallocatechin gallate) is a polyphenol from green tea that exerts neuroprotection through antioxidant and anti-inflammatory pathways, reducing neuronal damage and protein aggregation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:10:34.676Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuroprotection in neurodegenerative disease (specific indication not publicly detailed)"}]},"trialDetails":[{"nctId":"NCT02008721","phase":"PHASE3","title":"Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach","status":"COMPLETED","sponsor":"Dr. Johannes Levin","startDate":"2014-01","conditions":"Multiple System Atrophy","enrollment":92}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sunphenon EGCg"],"phase":"phase_3","status":"active","brandName":"EGCG as putative neuroprotective agent","genericName":"EGCG as putative neuroprotective agent","companyName":"Dr. Johannes Levin","companyId":"dr-johannes-levin","modality":"Small molecule","firstApprovalDate":"","aiSummary":"EGCG (epigallocatechin gallate) is a polyphenol from green tea that exerts neuroprotection through antioxidant and anti-inflammatory pathways, reducing neuronal damage and protein aggregation. Used for Neuroprotection in neurodegenerative disease (specific indication not publicly detailed).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}