{"id":"eflornithine-topical","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Folliculitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Eflornithine is an irreversible inhibitor of ornithine decarboxylase (ODC), an enzyme essential for polyamine biosynthesis. Polyamines are required for cell proliferation and hair follicle growth. By depleting polyamines in hair follicles, eflornithine slows the growth rate of hair, making it finer and lighter over time.","oneSentence":"Eflornithine inhibits ornithine decarboxylase, reducing polyamine synthesis and slowing hair growth.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:36:17.367Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of unwanted facial hair in women"}]},"trialDetails":[{"nctId":"NCT04091022","phase":"PHASE2","title":"Topical Diclofenac and Topical DFMO Chemoprevention Trial in Subjects With a History of Skin Cancer","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2021-01-18","conditions":"Non-melanoma Skin Cancer","enrollment":64},{"nctId":"NCT06976424","phase":"PHASE4","title":"Comparison of a Face Cream Plus a Laser Procedure and Face Cream Alone in Treatment of Excessive Face Hairs in Female","status":"RECRUITING","sponsor":"Khyber Teaching Hospital","startDate":"2025-07-15","conditions":"Hirsuitism","enrollment":122},{"nctId":"NCT06957834","phase":"PHASE2","title":"Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled Study","status":"COMPLETED","sponsor":"National Skin Centre","startDate":"2023-06-06","conditions":"Melasma","enrollment":20},{"nctId":"NCT04403282","phase":"PHASE4","title":"Topical Eflornithine for Pseudofolliculitis Barbae: Randomized Controlled Trial","status":"TERMINATED","sponsor":"Walter Reed National Military Medical Center","startDate":"2020-09-27","conditions":"Pseudofolliculitis Barbae","enrollment":9},{"nctId":"NCT00021294","phase":"PHASE2","title":"Eflornithine With or Without Triamcinolone in Preventing Nonmelanoma Skin Cancer in Patients With Actinic Keratosis","status":"COMPLETED","sponsor":"University of Arizona","startDate":"2001-05","conditions":"Non-melanomatous Skin Cancer, Precancerous/Nonmalignant Condition","enrollment":""},{"nctId":"NCT00601640","phase":"PHASE2","title":"Eflornithine and/or Diclofenac in Treating Patients With Sun-Damaged Skin","status":"COMPLETED","sponsor":"University of Arizona","startDate":"2007-01","conditions":"Other Benign Neoplasm of Skin, Unspecified","enrollment":184},{"nctId":"NCT01817894","phase":"PHASE4","title":"Treatment With Topical Eflornithin After Laser Treatment in Women With Facial Hirsutism","status":"COMPLETED","sponsor":"Bispebjerg Hospital","startDate":"2012-01","conditions":"Hirsutism","enrollment":22}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ELECTROCARDIOGRAM ST SEGMENT ELEVATION"},{"count":1,"reaction":"MYOCARDIAL INFARCTION"}],"_approvalHistory":[],"publicationCount":64,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Eflornithine cream"],"phase":"marketed","status":"active","brandName":"Eflornithine Topical","genericName":"Eflornithine Topical","companyName":"Khyber Teaching Hospital","companyId":"khyber-teaching-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Eflornithine inhibits ornithine decarboxylase, reducing polyamine synthesis and slowing hair growth. Used for Reduction of unwanted facial hair in women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}