{"id":"eflornithine-hydrochloride-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Folliculitis"},{"rate":null,"effect":"Burning or stinging at application site"}]},"_chembl":{"chemblId":"CHEMBL1201037","moleculeType":"Small molecule","molecularWeight":"236.65"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Eflornithine is an irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Polyamines are essential for cell proliferation and differentiation, including in hair follicles. By depleting polyamines in hair follicle cells, eflornithine reduces the rate of hair growth and can decrease hair density and thickness in unwanted facial hair.","oneSentence":"Eflornithine inhibits ornithine decarboxylase, an enzyme required for polyamine synthesis, thereby slowing hair growth in facial hirsutism.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:10:37.897Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of unwanted facial hair in women (hirsutism)"}]},"trialDetails":[{"nctId":"NCT04091022","phase":"PHASE2","title":"Topical Diclofenac and Topical DFMO Chemoprevention Trial in Subjects With a History of Skin Cancer","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2021-01-18","conditions":"Non-melanoma Skin Cancer","enrollment":64},{"nctId":"NCT06976424","phase":"PHASE4","title":"Comparison of a Face Cream Plus a Laser Procedure and Face Cream Alone in Treatment of Excessive Face Hairs in Female","status":"RECRUITING","sponsor":"Khyber Teaching Hospital","startDate":"2025-07-15","conditions":"Hirsuitism","enrollment":122},{"nctId":"NCT06957834","phase":"PHASE2","title":"Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled Study","status":"COMPLETED","sponsor":"National Skin Centre","startDate":"2023-06-06","conditions":"Melasma","enrollment":20},{"nctId":"NCT00021294","phase":"PHASE2","title":"Eflornithine With or Without Triamcinolone in Preventing Nonmelanoma Skin Cancer in Patients With Actinic Keratosis","status":"COMPLETED","sponsor":"University of Arizona","startDate":"2001-05","conditions":"Non-melanomatous Skin Cancer, Precancerous/Nonmalignant Condition","enrollment":""},{"nctId":"NCT01817894","phase":"PHASE4","title":"Treatment With Topical Eflornithin After Laser Treatment in Women With Facial Hirsutism","status":"COMPLETED","sponsor":"Bispebjerg Hospital","startDate":"2012-01","conditions":"Hirsutism","enrollment":22},{"nctId":"NCT00176995","phase":"PHASE2","title":"Effect of 15% Eflornithine Hydrochloride Cream on African-American Males With Pseudofolliculitis Barbae","status":"COMPLETED","sponsor":"Hordinsky, Maria K., MD","startDate":"1999-03","conditions":"Pseudofolliculitis Barbae","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["DFMO","CPP-1X placebo","Vaniqa"],"phase":"phase_3","status":"active","brandName":"Eflornithine hydrochloride cream","genericName":"Eflornithine hydrochloride cream","companyName":"National Skin Centre","companyId":"national-skin-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Eflornithine inhibits ornithine decarboxylase, an enzyme required for polyamine synthesis, thereby slowing hair growth in facial hirsutism. Used for Reduction of unwanted facial hair in women (hirsutism).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}