{"id":"efinaconazole-topical","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site erythema"},{"rate":null,"effect":"Application site pruritus"},{"rate":null,"effect":"Nail discoloration"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL2103877","moleculeType":"Small molecule","molecularWeight":"348.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By blocking the cytochrome P450-dependent enzyme lanosterol 14α-demethylase, efinaconazole prevents the conversion of lanosterol to ergosterol, a critical component of fungal cell membranes. This leads to accumulation of toxic sterol precursors and membrane destabilization, ultimately causing fungal cell death. The topical formulation allows high local concentrations at the site of infection while minimizing systemic exposure.","oneSentence":"Efinaconazole is a triazole antifungal that inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol synthesis in fungal cell membranes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:46:09.800Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Onychomycosis (fungal nail infection)"}]},"trialDetails":[{"nctId":"NCT07382427","phase":"PHASE2","title":"A Phase 2 Study to Assess the Effectiveness of Topical Terbinafine in Participants With Mild to Moderate Onychomycosis of the Toenails","status":"NOT_YET_RECRUITING","sponsor":"Onyx Axiom","startDate":"2026-03","conditions":"Onychomycosis of Toenail","enrollment":200},{"nctId":"NCT02812771","phase":"PHASE4","title":"Safety and Pharmacokinetics of Efinaconazole Topical Solution in Subjects With Mild to Severe Onychomycosis","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2016-08-04","conditions":"Onychomycosis","enrollment":62},{"nctId":"NCT03280927","phase":"PHASE4","title":"Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Jublia® in Mild to Moderate Toenail Onychomycosis","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2017-11-10","conditions":"Mild to Moderate Onychomycosis Due to Dermatophyte","enrollment":97},{"nctId":"NCT03168841","phase":"PHASE3","title":"Efficacy and Safety of Efinaconazole 10% Solution in the Treatment of Onychomycosis in Diabetic Patients","status":"COMPLETED","sponsor":"Western University of Health Sciences","startDate":"2017-06-06","conditions":"Onychomycosis","enrollment":40},{"nctId":"NCT03098615","phase":"PHASE4","title":"Study Evaluating the Effect of Jublia on Dermatophytomas","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2015-09","conditions":"Onychomycosis, Dermatophytosis","enrollment":19},{"nctId":"NCT03110029","phase":"PHASE4","title":"Evaluating the Efficacy and Compatibility of Efinaconazole 10% Solution (Jublia) for the Treatment of Toenail Onychomycosis in Patients Wearing Toenail Polish Compared to Those Without Polish","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2015-09","conditions":"Onychomycosis of Toenail","enrollment":13}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Efinaconazole Topical","genericName":"Efinaconazole Topical","companyName":"Western University of Health Sciences","companyId":"western-university-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Efinaconazole Topical is a small molecule inhibitor of lanosterol 14-alpha demethylase, classified as an INHIBITOR. It is used to treat conditions such as onychomycosis of the toenail, onychomycosis, and dermatophytosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}