{"id":"effervescent-paracetamol-termalgin","safety":{"commonSideEffects":[{"rate":null,"effect":"Hepatotoxicity (at high doses)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paracetamol (acetaminophen) works primarily through inhibition of central cyclooxygenase (COX) enzymes, which decreases prostaglandin production in the brain and spinal cord. This leads to reduced pain perception and lowering of the hypothalamic temperature set point. The effervescent formulation enhances rapid absorption and onset of action compared to standard tablets.","oneSentence":"Paracetamol inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes, reducing pain and fever.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:36:10.944Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT02514538","phase":"PHASE4","title":"EVALUATION OF THE RELATIONSHIP BETWEEN EFFERVESCENT PARACETAMOL AND BLOOD PRESSURE. CLINICAL TRIAL.","status":"UNKNOWN","sponsor":"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina","startDate":"2012-02","conditions":"Hypertension, Chronic Disease of Musculoskeletal System","enrollment":49}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Effervescent paracetamol termalgin","genericName":"Effervescent paracetamol termalgin","companyName":"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina","companyId":"fundacio-d-investigacio-en-atencio-primaria-jordi-gol-i-gurina","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paracetamol inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes, reducing pain and fever. Used for Mild to moderate pain, Fever reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}