{"id":"edrophonium","rwe":[{"pmid":"41664151","year":"2026","title":"Diagnostic performance and safety of the edrophonium test in myasthenia gravis: a retrospective case-control study.","finding":"","journal":"Neurological research and practice","studyType":"Clinical Study"},{"pmid":"41439073","year":"2025","title":"Cavernous Sinus Dural Arteriovenous Fistula Initially Misdiagnosed As Ocular Myasthenia Gravis: A Case Report.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"41398384","year":"2025","title":"Genome-wide meta-analysis with 2,206,440 individuals identifies 322 novel risk loci for obesity.","finding":"","journal":"International journal of obesity (2005)","studyType":"Clinical Study"},{"pmid":"41338982","year":"2025","title":"Generalized Myasthenia Gravis with Anti-acetylcholine Receptor Antibodies during the Clinical Course of Spinal and Bulbar Muscular Atrophy: A Case Report.","finding":"","journal":"Internal medicine (Tokyo, 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dysreflexia","Benign prostatic hyperplasia","Bladder outflow obstruction","Bleeding","Brain damage","Chronic heart failure","Chronic lung disease","Complete trisomy 21 syndrome","Conduction disorder of the heart","Disease of liver","Disorder of coronary artery","Disturbance of salivary secretion","Drowsy","Drug AND/OR toxin-induced diarrhea","Gastric ulcer","Gastrointestinal obstruction","Hiatal hernia","Hypertensive disorder","Hyperthyroidism","Kidney disease","Myasthenia gravis"],"seriousAdverseEvents":[{"effect":"Bradycardia","drugRate":"","severity":"serious"},{"effect":"Cardiac standstill","drugRate":"","severity":"serious"},{"effect":"Severe cholinergic reactions","drugRate":"","severity":"serious"},{"effect":"Laryngospasm","drugRate":"","severity":"serious"},{"effect":"Bronchiolar constriction","drugRate":"","severity":"serious"},{"effect":"Paralysis of muscles of respiration","drugRate":"","severity":"serious"},{"effect":"Central respiratory 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targets acetylcholinesterase. Originally developed in the 1950s, it is now owned by Pai Holdings Pharm and is used to treat various neuromuscular conditions, including curare overdose and myasthenia gravis. Tensilon is a generic medication, off-patent since it has no active Orange Book patents, and is manufactured by multiple generic manufacturers. It has a short half-life of 1.8 hours and is administered via injection. Key safety considerations include its potential to cause bradycardia and hypotension.","approvals":[{"date":"1951-05-03","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Tensilon","ecosystem":[{"indication":"Curare Overdose","otherDrugs":[],"globalPrevalence":null},{"indication":"Diagnostic Test for Myasthenia Gravis","otherDrugs":[],"globalPrevalence":621600},{"indication":"Neuromuscular Block due to Nondepolarizing Drug","otherDrugs":[{"name":"pyridostigmine","slug":"pyridostigmine","company":"Valeant Pharms Llc"}],"globalPrevalence":null},{"indication":"Reversal of neuromuscular blockade","otherDrugs":[{"name":"neostigmine","slug":"neostigmine","company":"Eclat Pharms Llc"},{"name":"sugammadex","slug":"sugammadex","company":"Organon Usa 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