{"id":"edoxudine","rwe":[{"pmid":"41480139","year":"2022","title":"New findings on ligand series used as SARS-CoV-2 virus inhibitors within the frameworks of molecular docking, molecular quantum similarity and chemical reactivity indices.","finding":"","journal":"F1000Research","studyType":"Clinical Study"},{"pmid":"37555596","year":"2024","title":"In-silico investigation of E8 surface protein of the monkeypox virus to identify potential therapeutic agents.","finding":"","journal":"Journal of biomolecular structure & dynamics","studyType":"Clinical Study"},{"pmid":"32794216","year":"2020","title":"Metabolite profiling of arginase inhibitor activity guided fraction of Ficus religiosa leaves by LC-HRMS.","finding":"","journal":"Biomedical chromatography : BMC","studyType":"Clinical Study"},{"pmid":"14743269","year":"1998","title":"Topical antiviral agents for herpes simplex virus infections.","finding":"","journal":"Drugs of today (Barcelona, Spain : 1998)","studyType":"Clinical Study"},{"pmid":"8032338","year":"1994","title":"Structure-activity relationships and conformational features of antiherpetic pyrimidine and purine nucleoside analogues. A review.","finding":"","journal":"Pharmacy world & science : PWS","studyType":"Clinical Study"}],"tags":[{"label":"edoxudine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D06BB09","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"epoxudine","offLabel":[],"synonyms":["edoxudine","epoxudine"],"timeline":[],"aiSummary":"Epoxudine is a small molecule with the chemical name 5-ethyl-3-(2'-deoxyribosyl)uracil. It is also known by other synonyms, including edoxudina, edoxudine, and edoxudine.","approvals":[],"brandName":"Epoxudine","ecosystem":[],"mechanism":{"target":"Thymidine kinase","modality":"Small Molecule","drugClass":"edoxudine","explanation":"Imagine your body's cells are like factories that make copies of a virus. Edoxudine is like a tool that tries to stop the factory from making more copies of the virus, but it's not entirely clear how it does this. More research is needed to understand how it works.","oneSentence":"Edoxudine is thought to work by inhibiting viral replication, although the exact mechanism is unclear.","technicalDetail":"Edoxudine is a nucleoside analog that may interfere with viral DNA synthesis, although the precise molecular mechanism is unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3173","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=EDOXUDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:52:09.276318","biosimilars":[],"competitors":[{"drugName":"idoxuridine","drugSlug":"idoxuridine","fdaApproval":"1963-06-11","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"acyclovir","drugSlug":"acyclovir","fdaApproval":"1982-03-29","patentExpiry":"Mar 23, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"podophyllotoxin","drugSlug":"podophyllotoxin","fdaApproval":"1990-12-13","relationship":"same-class"},{"drugName":"inosine","drugSlug":"inosine","fdaApproval":"","relationship":"same-class"},{"drugName":"penciclovir","drugSlug":"penciclovir","fdaApproval":"1996-09-24","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"imiquimod","drugSlug":"imiquimod","fdaApproval":"1997-02-27","patentExpiry":"Dec 11, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"docosanol","drugSlug":"docosanol","fdaApproval":"2000-07-25","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sinecatechins","drugSlug":"sinecatechins","fdaApproval":"2006-10-31","patentExpiry":"Oct 2, 2026","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"edoxudine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"idoxuridine","brandName":"idoxuridine","genericName":"idoxuridine","approvalYear":"1963","relationship":"same-class"},{"drugId":"acyclovir","brandName":"acyclovir","genericName":"acyclovir","approvalYear":"1982","relationship":"same-class"},{"drugId":"podophyllotoxin","brandName":"podophyllotoxin","genericName":"podophyllotoxin","approvalYear":"1990","relationship":"same-class"},{"drugId":"inosine","brandName":"inosine","genericName":"inosine","approvalYear":"","relationship":"same-class"},{"drugId":"penciclovir","brandName":"penciclovir","genericName":"penciclovir","approvalYear":"1996","relationship":"same-class"},{"drugId":"imiquimod","brandName":"imiquimod","genericName":"imiquimod","approvalYear":"1997","relationship":"same-class"},{"drugId":"docosanol","brandName":"docosanol","genericName":"docosanol","approvalYear":"2000","relationship":"same-class"},{"drugId":"sinecatechins","brandName":"sinecatechins","genericName":"sinecatechins","approvalYear":"2006","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"005116","UNII":"15ZQM81Y3R","CHEBI":"CHEBI:135051","INN_ID":"5512","RXNORM":"49428","UMLSCUI":"C0115510","ChEMBL_ID":"CHEMBL318153","KEGG_DRUG":"D03956","DRUGBANK_ID":"DB13421","PUBCHEM_CID":"66377"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"D06BB09","allCodes":["D06BB09"]},"biosimilarFilings":[],"recentPublications":[{"date":"2022","pmid":"41480139","title":"New findings on ligand series used as SARS-CoV-2 virus inhibitors within the frameworks of molecular docking, molecular quantum similarity and chemical reactivity indices.","journal":"F1000Research"},{"date":"2024 Oct","pmid":"37555596","title":"In-silico investigation of E8 surface protein of the monkeypox virus to identify potential therapeutic agents.","journal":"Journal of biomolecular structure & dynamics"},{"date":"2020 Dec","pmid":"32794216","title":"Metabolite profiling of arginase inhibitor activity guided fraction of Ficus religiosa leaves by LC-HRMS.","journal":"Biomedical chromatography : BMC"},{"date":"1998 Dec","pmid":"14743269","title":"Topical antiviral agents for herpes simplex virus infections.","journal":"Drugs of today (Barcelona, Spain : 1998)"},{"date":"1994 Apr 15","pmid":"8032338","title":"Structure-activity relationships and conformational features of antiherpetic pyrimidine and purine nucleoside analogues. A review.","journal":"Pharmacy world & science : PWS"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}