{"id":"edetic-acid","rwe":[{"pmid":"41096180","year":"2025","title":"In Vitro Evaluation of Antimicrobial Effects of Endodontic Irrigants Containing Disodium Edetate and Chlorhexidine Gluconate, Octenidine Dihydrochloride, and Benzalkonium Bromide Against Intracanal Enterococcus faecalis.","finding":"","journal":"Journal of clinical medicine","studyType":"Clinical Study"},{"pmid":"40823112","year":"2025","title":"Effect of EDTA and silane on the bond strength of cementing agents of glass fiber posts to root dentin.","finding":"","journal":"Journal of clinical and experimental dentistry","studyType":"Clinical Study"},{"pmid":"39434302","year":"2024","title":"Effect of 532nm and 589nm Diode-Pumped Solid-State (DPSS) Lasers with Different Doses on Concentration of Total Protein and Albumin in Vitro.","finding":"","journal":"JPMA. The Journal of the Pakistan Medical Association","studyType":"Clinical Study"},{"pmid":"39065268","year":"2024","title":"Inhibition of Microbial Growth and Biofilm Formation in Pure and Mixed Bacterial Samples.","finding":"","journal":"Microorganisms","studyType":"Clinical Study"},{"pmid":"38945113","year":"2024","title":"Comparison of plasma clearance of [(51)Cr]CrEDTA based on three, two and single samples to measure the glomerular filtration rate in patients with solid tumors: a prospective cross-sectional analysis.","finding":"","journal":"Clinics (Sao Paulo, Brazil)","studyType":"Clinical Study"}],"tags":[{"label":"Anti-coagulant","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Amyloid beta A4 protein","category":"target"},{"label":"APP","category":"gene"},{"label":"ACE","category":"gene"},{"label":"EYA2","category":"gene"},{"label":"Topical","category":"route"},{"label":"Intramuscular","category":"route"},{"label":"Dental","category":"route"},{"label":"Concentrate","category":"form"},{"label":"Cream","category":"form"},{"label":"Gel","category":"form"},{"label":"Injection","category":"form"},{"label":"Active","category":"status"},{"label":"Accidental poisoning by lead and its compounds and fumes","category":"indication"},{"label":"Digitalis toxicity by EKG","category":"indication"},{"label":"Hypercalcemia","category":"indication"},{"label":"Medicis","category":"company"},{"label":"Approved 1950s","category":"decade"},{"label":"Anticoagulants","category":"pharmacology"},{"label":"Calcium Chelating Agents","category":"pharmacology"},{"label":"Chelating Agents","category":"pharmacology"},{"label":"Food Additives","category":"pharmacology"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Sequestering Agents","category":"pharmacology"}],"phase":"marketed","safety":{"safetySignals":[{"llr":419.067,"date":"","count":91,"signal":"Gastrointestinal toxicity","source":"DrugCentral FAERS","actionTaken":"Reported 91 times (LLR=419)"},{"llr":384.981,"date":"","count":90,"signal":"Pulmonary toxicity","source":"DrugCentral FAERS","actionTaken":"Reported 90 times (LLR=385)"},{"llr":313.593,"date":"","count":90,"signal":"Joint injury","source":"DrugCentral FAERS","actionTaken":"Reported 90 times (LLR=314)"},{"llr":291.407,"date":"","count":91,"signal":"Neoplasm malignant","source":"DrugCentral FAERS","actionTaken":"Reported 91 times (LLR=291)"},{"llr":273.651,"date":"","count":91,"signal":"Hepatotoxicity","source":"DrugCentral FAERS","actionTaken":"Reported 91 times (LLR=274)"},{"llr":267.722,"date":"","count":87,"signal":"C-reactive protein abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 87 times (LLR=268)"},{"llr":231.786,"date":"","count":77,"signal":"Joint stiffness","source":"DrugCentral FAERS","actionTaken":"Reported 77 times (LLR=232)"},{"llr":216.119,"date":"","count":91,"signal":"Musculoskeletal pain","source":"DrugCentral FAERS","actionTaken":"Reported 91 times (LLR=216)"},{"llr":215.468,"date":"","count":90,"signal":"Therapy non-responder","source":"DrugCentral FAERS","actionTaken":"Reported 90 times (LLR=215)"},{"llr":158.575,"date":"","count":91,"signal":"Musculoskeletal stiffness","source":"DrugCentral FAERS","actionTaken":"Reported 91 times (LLR=159)"},{"llr":146.604,"date":"","count":90,"signal":"Treatment failure","source":"DrugCentral FAERS","actionTaken":"Reported 90 times (LLR=147)"},{"llr":135.762,"date":"","count":75,"signal":"Therapeutic product effect incomplete","source":"DrugCentral FAERS","actionTaken":"Reported 75 times (LLR=136)"},{"llr":125.346,"date":"","count":90,"signal":"Infection","source":"DrugCentral FAERS","actionTaken":"Reported 90 times (LLR=125)"},{"llr":113.174,"date":"","count":90,"signal":"Joint swelling","source":"DrugCentral FAERS","actionTaken":"Reported 90 times (LLR=113)"},{"llr":112.483,"date":"","count":94,"signal":"Pain in extremity","source":"DrugCentral FAERS","actionTaken":"Reported 94 times (LLR=112)"}],"commonSideEffects":[],"contraindications":["Acute nephropathy","Anuria","Cerebral edema","Chronic heart failure","Dehydration","Disease of liver","Epilepsy","Hypocalcemia","Hypokalemia","Inflammatory disease of liver","Kidney disease","Lesion of brain","Oliguria","Pulmonary tuberculosis"],"specialPopulations":{"Pregnancy":"Category One reproduction study was performed in rats at doses up to 13 times the human dose and revealed no evidence of impaired fertility or harm to the fetus due to edetate calcium disodium. Another reproduction study performed in rats at doses up to about 25 to 40 times the human dose revealed evidence of fetal malformations due to edetate calcium disodium, which were prevented by simultaneous supplementation of dietary zinc. There are, however, no adequate and well-controlled studies in pregnant women. Use in pregnancy only when clearly needed.","Paediatric use":"Since lead poisoning occurs in pediatric populations and adults but is frequently more severe in pediatric patients, edetate calcium disodium is used in patients of all ages. The intramuscular route is preferred by some for young pediatric patients. In cases where the intravenous route is necessary, avoid rapid infusion. Urine flow must be monitored throughout therapy; Edetate Calcium Disodium therapy must be stopped if anuria or severe oliguria develops.","Renal impairment":"Urine flow must be monitored throughout therapy; Edetate Calcium Disodium therapy must be stopped if anuria or severe oliguria develops."}},"trials":[],"aliases":[],"company":"Medicis","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=EDETIC ACID","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:20:08.513329+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:20:14.064900+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=EDETIC ACID","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:20:14.403524+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL858/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:20:15.655961+00:00"}},"allNames":"calcium disodium versenate","offLabel":[],"synonyms":["edetate disodium","edetic acid","EDTA","edathamil","endrate","ethylenedinitrilotetraacetic acid","edetate calcium disodium","calcium disodium versenate"],"timeline":[{"date":"1953-07-16","type":"positive","source":"DrugCentral","milestone":"FDA approval (Medicis)"}],"approvals":[{"date":"1953-07-16","orphan":false,"company":"MEDICIS","regulator":"FDA"}],"brandName":"Calcium Disodium Versenate","ecosystem":[{"indication":"Accidental poisoning by lead and its compounds and fumes","otherDrugs":[{"name":"dimercaprol","slug":"dimercaprol","company":"Akorn"},{"name":"succimer","slug":"succimer","company":"Recordati Rare"}],"globalPrevalence":null},{"indication":"Digitalis toxicity by EKG","otherDrugs":[],"globalPrevalence":null},{"indication":"Hypercalcemia","otherDrugs":[{"name":"ibandronic acid","slug":"ibandronic-acid","company":"Hoffmann La Roche"}],"globalPrevalence":null}],"mechanism":{"target":"Amyloid beta A4 protein","novelty":"First-in-class","targets":[{"gene":"APP","source":"DrugCentral","target":"Amyloid beta A4 protein","protein":"Amyloid beta A4 protein"},{"gene":"ACE","source":"DrugCentral","target":"Angiotensin-converting enzyme","protein":"Angiotensin-converting enzyme"},{"gene":"EYA2","source":"DrugCentral","target":"Eyes absent homolog 2","protein":"Eyes absent homolog 2"},{"gene":"UGCG","source":"DrugCentral","target":"Ceramide glucosyltransferase","protein":"Ceramide glucosyltransferase"}],"moaClass":"Calcium Chelating Activity","modality":"Small Molecule","drugClass":"Anti-coagulant","explanation":"","oneSentence":"","technicalDetail":"Edetic Acid is a hexadentate ligand that forms a stable complex with metal ions, such as lead, through multiple coordination bonds, effectively sequestering the metal and preventing its toxic effects."},"commercial":{"launchDate":"1953","_launchSource":"DrugCentral (FDA 1953-07-16, MEDICIS)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/987","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=EDETIC%20ACID","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=EDETIC ACID","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:56:11.981685","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:20:17.304081+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"alacepril","drugSlug":"alacepril","fdaApproval":"1981-04-06","relationship":"same-target"},{"drugName":"benazepril","drugSlug":"benazepril","fdaApproval":"1991-06-25","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"captopril","drugSlug":"captopril","fdaApproval":"1981-04-06","genericCount":21,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"enalapril","drugSlug":"enalapril","fdaApproval":"1985-12-24","patentExpiry":"Nov 6, 2032","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"enalaprilat","drugSlug":"enalaprilat","fdaApproval":"1988-02-09","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"fosinopril","drugSlug":"fosinopril","fdaApproval":"1991-05-16","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"lisinopril","drugSlug":"lisinopril","fdaApproval":"1987-12-29","patentExpiry":"Nov 6, 2035","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"losartan","drugSlug":"losartan","fdaApproval":"1995-04-14","patentExpiry":"Oct 7, 2041","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"moexipril","drugSlug":"moexipril","fdaApproval":"1995-04-19","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"perindopril","drugSlug":"perindopril","fdaApproval":"1993-12-30","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"genericName":"edetic acid","indications":{"approved":[{"name":"Accidental poisoning by lead and its compounds and fumes","source":"DrugCentral","snomedId":216777009,"regulator":"FDA"},{"name":"Digitalis toxicity by EKG","source":"DrugCentral","snomedId":6412007,"regulator":"FDA"},{"name":"Hypercalcemia","source":"DrugCentral","snomedId":66931009,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"alacepril","brandName":"alacepril","genericName":"alacepril","approvalYear":"1981","relationship":"same-target"},{"drugId":"benazepril","brandName":"benazepril","genericName":"benazepril","approvalYear":"1991","relationship":"same-target"},{"drugId":"captopril","brandName":"captopril","genericName":"captopril","approvalYear":"1981","relationship":"same-target"},{"drugId":"enalapril","brandName":"enalapril","genericName":"enalapril","approvalYear":"1985","relationship":"same-target"},{"drugId":"enalaprilat","brandName":"enalaprilat","genericName":"enalaprilat","approvalYear":"1988","relationship":"same-target"},{"drugId":"fosinopril","brandName":"fosinopril","genericName":"fosinopril","approvalYear":"1991","relationship":"same-target"},{"drugId":"lisinopril","brandName":"lisinopril","genericName":"lisinopril","approvalYear":"1987","relationship":"same-target"},{"drugId":"losartan","brandName":"losartan","genericName":"losartan","approvalYear":"1995","relationship":"same-target"},{"drugId":"moexipril","brandName":"moexipril","genericName":"moexipril","approvalYear":"1995","relationship":"same-target"},{"drugId":"perindopril","brandName":"perindopril","genericName":"perindopril","approvalYear":"1993","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT06982222","phase":"PHASE1","title":"Testing 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