{"id":"ecabet","rwe":[{"pmid":"41442424","year":"2026","title":"A Network Meta-Analysis of Pharmacological Treatments for Gastric Mucosal Protection in Artificial Ulcers following Endoscopic Submucosal Dissection of the Stomach.","finding":"","journal":"Pharmacology","studyType":"Clinical Study"},{"pmid":"40701088","year":"2025","title":"Identification of rice taste quality markers using metabolomics techniques.","finding":"","journal":"Food chemistry","studyType":"Clinical Study"},{"pmid":"36161753","year":"2023","title":"Structural and mechanistic insights into the precise product synthesis by a bifunctional miltiradiene synthase.","finding":"","journal":"Plant biotechnology journal","studyType":"Clinical Study"},{"pmid":"31996319","year":"2020","title":"Evaluating the mucoprotective effect of polydeoxyribonucleotide against indomethacin-induced gastropathy via the MAPK/NF-κB signaling pathway in rats.","finding":"","journal":"European journal of pharmacology","studyType":"Clinical Study"},{"pmid":"31067267","year":"2019","title":"Risk of post-stroke pneumonia with proton pump inhibitors, H2 receptor antagonists and mucoprotective agents: A retrospective nationwide cohort study.","finding":"","journal":"PloS one","studyType":"Clinical Study"}],"tags":[{"label":"ecabet","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Peptic ulcer","category":"indication"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Ulcer Agents","category":"pharmacology"},{"label":"Anticarcinogenic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Protease Inhibitors","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["TA-2711","ecabet","ecabet sodium"],"offLabel":[],"synonyms":["TA-2711","ecabet","ecabet sodium"],"timeline":[],"approvals":[],"ecosystem":[{"indication":"Peptic ulcer","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"chlordiazepoxide","slug":"chlordiazepoxide","company":"Valeant Pharm Intl"},{"name":"dexlansoprazole","slug":"dexlansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":64000000}],"mechanism":{"modality":"Small Molecule","drugClass":"ecabet","explanation":"Imagine your stomach is like a washing machine, and pepsin is the detergent that breaks down food into smaller pieces. ECABET is like a detergent inhibitor that reduces the amount of pepsin available to break down food, allowing the stomach lining to heal. This helps to reduce inflammation and promote healing in the stomach lining.","oneSentence":"ECABET works by inhibiting pepsin, an enzyme that breaks down food in the stomach.","technicalDetail":"ECABET acts as a reversible inhibitor of gastric pepsin, specifically targeting the active site of the enzyme to reduce its activity and subsequent gastric acid production."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/981","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ECABET","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ECABET","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:51:17.692257","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:41:09.056631+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"ecabet","indications":{"approved":[{"name":"Peptic ulcer","source":"DrugCentral","snomedId":13200003,"regulator":"FDA","usPrevalence":null,"globalPrevalence":64000000,"prevalenceMethod":"curated","prevalenceSource":"Aliment Pharmacol Ther, 2009 (PMID:19220208)"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00667004","phase":"PHASE2","title":"Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease","status":"COMPLETED","sponsor":"Bausch & Lomb Incorporated","startDate":"2008-03-22","conditions":["Dry Eye Disease"],"enrollment":183,"completionDate":"2008-09-12"},{"nctId":"NCT00370747","phase":"PHASE2","title":"Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome","status":"COMPLETED","sponsor":"Bausch & Lomb Incorporated","startDate":"2006-09","conditions":["Dry Eye Syndromes"],"enrollment":162,"completionDate":"2007-06"},{"nctId":"NCT00198536","phase":"PHASE2,PHASE3","title":"Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome","status":"COMPLETED","sponsor":"Bausch & Lomb Incorporated","startDate":"2005-04","conditions":["Dry Eye Syndromes"],"enrollment":159,"completionDate":"2005-12"},{"nctId":"NCT01039558","phase":"NA","title":"The Effect of Lansoprazole in Combination With Ecabet Sodium for Gastroesophageal Reflux Disease","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2009-12","conditions":["Gastroesophageal Reflux Disease"],"enrollment":30,"completionDate":"2011-03"},{"nctId":"NCT01308177","phase":"PHASE4","title":"Efficacy of Ecabet Sodium and Proton Pump Inhibitor Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection","status":"UNKNOWN","sponsor":"Samsung Medical Center","startDate":"2011-03","conditions":["Delayed Bleeding,","Healing Ulcer","Quality of Ulcer"],"enrollment":90,"completionDate":"2012-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"010971","UNII":"2K02669KWP","CHEBI":"CHEBI:135593","INN_ID":"6742","UMLSCUI":"C0209315","ChEMBL_ID":"CHEMBL2104585","KEGG_DRUG":"D07885","DRUGBANK_ID":"DB05265","PUBCHEM_CID":"65781","SECONDARY_CAS_RN":"86408-72-2","MESH_SUPPLEMENTAL_RECORD_UI":"C061681"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":100,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026","pmid":"41442424","title":"A Network Meta-Analysis of Pharmacological Treatments for Gastric Mucosal Protection in Artificial Ulcers following Endoscopic Submucosal Dissection of the Stomach.","journal":"Pharmacology"},{"date":"2025 Nov 15","pmid":"40701088","title":"Identification of rice taste quality markers using metabolomics techniques.","journal":"Food chemistry"},{"date":"2023 Jan","pmid":"36161753","title":"Structural and mechanistic insights into the precise product synthesis by a bifunctional miltiradiene synthase.","journal":"Plant biotechnology journal"},{"date":"2020 May 5","pmid":"31996319","title":"Evaluating the mucoprotective effect of polydeoxyribonucleotide against indomethacin-induced gastropathy via the MAPK/NF-κB signaling pathway in rats.","journal":"European journal of pharmacology"},{"date":"2019","pmid":"31067267","title":"Risk of post-stroke pneumonia with proton pump inhibitors, H2 receptor antagonists and mucoprotective agents: A retrospective nationwide cohort study.","journal":"PloS one"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"ECABET","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ecabet sodium is a small molecule used in clinical trials for conditions such as gastroesophageal reflux disease, delayed bleeding, healing ulcers, quality of ulcers, and dry eye syndromes. It has been studied in combination with lansoprazole for the treatment of gastroesophageal reflux disease in a randomized controlled trial.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":1,"withResults":1},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:41:09.056631+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}