{"id":"early-vasopressin","safety":{"commonSideEffects":[{"rate":null,"effect":"Peripheral vasoconstriction / ischemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Cardiac arrhythmias"},{"rate":null,"effect":"Mesenteric ischemia"}]},"_chembl":{"chemblId":"CHEMBL1201528","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vasopressin (antidiuretic hormone) binds to V1 receptors on vascular smooth muscle cells, causing vasoconstriction and increased systemic vascular resistance. 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the TerliNor Study","status":"UNKNOWN","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2018-07-27","conditions":"Septic Shock","enrollment":40},{"nctId":"NCT00966355","phase":"PHASE4","title":"Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding","status":"COMPLETED","sponsor":"Korea University","startDate":"2006-09","conditions":"Variceal Bleeding, Cirrhosis","enrollment":1034},{"nctId":"NCT02468063","phase":"NA","title":"To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock","status":"COMPLETED","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2015-05-01","conditions":"Cirrhosis With Septic Shock","enrollment":184},{"nctId":"NCT01612676","phase":"PHASE2","title":"Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2012-06","conditions":"Septic Shock","enrollment":31},{"nctId":"NCT02757703","phase":"PHASE4","title":"Vasoactive Drugs in Real World Practice","status":"COMPLETED","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2010-05","conditions":"Vasoconstrictor Choice on Acute Variceal Bleeding","enrollment":150},{"nctId":"NCT01271114","phase":"PHASE3","title":"Hypertonic Saline and Terlipressin for Sepsis-associated Hypotension","status":"TERMINATED","sponsor":"Hospital General de Ciudad Real","startDate":"2012-06","conditions":"Septic Shock, Sepsis-associated Hypotension","enrollment":21},{"nctId":"NCT02053675","phase":"NA","title":"Hemodynamic Effects of Vasopressin in Early Septic Shock Stage","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2008-05","conditions":"Septic Shock","enrollment":18},{"nctId":"NCT01382134","phase":"NA","title":"Effect of Aspirin, Hemodilution and Desmopressin on Platelet Dysfunction","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2011-07","conditions":"Platelet Dysfunction, Hemodilution, Mild Hypothermia","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":31,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Early Vasopressin","genericName":"Early Vasopressin","companyName":"Hospital do Coracao","companyId":"hospital-do-coracao","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Early Vasopressin is a vasopressin analog that acts as a vasoconstrictor to increase blood pressure and peripheral vascular resistance in acute hypotensive states. Used for Acute hypotension and distributive shock (septic shock, post-operative hypotension), Variceal bleeding with hypotension.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}