{"id":"early-intravenous-tranexamic-acid-administration","safety":{"commonSideEffects":[{"rate":null,"effect":"Thromboembolic events (deep vein thrombosis, pulmonary embolism)"},{"rate":null,"effect":"Seizures"},{"rate":null,"effect":"Visual disturbances"},{"rate":null,"effect":"Gastrointestinal disturbances"}]},"_chembl":{"chemblId":"CHEMBL877","moleculeType":"Small molecule","molecularWeight":"157.21"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tranexamic acid is an antifibrinolytic agent that competitively inhibits the conversion of plasminogen to plasmin, preventing the breakdown of fibrin clots. Early intravenous administration in acute hemorrhage settings aims to reduce mortality and transfusion requirements by stabilizing clot formation during the critical early phase of injury.","oneSentence":"Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing excessive bleeding in acute trauma and hemorrhage.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:10:28.173Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute traumatic hemorrhage (early intravenous administration)"},{"name":"Reduction of blood loss and transfusion requirements in trauma patients"}]},"trialDetails":[{"nctId":"NCT04910464","phase":"PHASE3","title":"Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis","status":"RECRUITING","sponsor":"Assiut University","startDate":"2021-06-05","conditions":"Sepsis","enrollment":80},{"nctId":"NCT06760078","phase":"PHASE4","title":"Tranexamic Acid with Intensive Blood Pressure Management in Ultra-Early Intracerebral Hemorrhage","status":"NOT_YET_RECRUITING","sponsor":"Xuanwu Hospital, Beijing","startDate":"2024-12-31","conditions":"Spontaneous Intracranial Hemorrhage, Hypertension","enrollment":532},{"nctId":"NCT05696951","phase":"NA","title":"Tranexamic Acid in Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Goztepe Prof Dr Suleyman Yalcın City Hospital","startDate":"2022-01-01","conditions":"Tranexamic Acid Adverse Reaction","enrollment":200},{"nctId":"NCT04788121","phase":"PHASE3","title":"Efficacy of Tranexamic Acid in Upper Gastrointestinal Bleeding","status":"UNKNOWN","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2020-11-01","conditions":"Gastro Intestinal Bleeding","enrollment":160},{"nctId":"NCT03044184","phase":"PHASE3","title":"Tranexamic Acid for Spontaneous Acute Cerebral Hemorrhage Trial","status":"UNKNOWN","sponsor":"Kwong Wah Hospital","startDate":"2017-04-01","conditions":"Stroke Hemorrhagic, Intracerebral Haemorrhage","enrollment":220},{"nctId":"NCT03023189","phase":"PHASE4","title":"Efficacity and Safety of Tranexamic Acid in Cirrhotic Patients Presenting With Acute Upper Gastrointestinal Bleeding","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2017-04-03","conditions":"Upper Digestive Bleeding, Cirrhosis","enrollment":500},{"nctId":"NCT01713101","phase":"PHASE3","title":"Tranexamic Acid for Upper Gastrointestinal Bleeding","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2012-10","conditions":"Acute Upper Gastrointestinal Hemorrhage","enrollment":414}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["tranexamic acid administration","transamine administration","antifibrinolytics administration"],"phase":"phase_3","status":"active","brandName":"Early intravenous tranexamic acid administration","genericName":"Early intravenous tranexamic acid administration","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing excessive bleeding in acute trauma and hemorrhage. Used for Acute traumatic hemorrhage (early intravenous administration), Reduction of blood loss and transfusion requirements in trauma patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}